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Xiaotan Jieyu Prescription Alleviates Breast Precancerous Lesions through PI3KAkt Signaling Pathway
المؤلفون المشاركون
Yue, Xiaoqiang
Yu, Chaoqin
Sun, Dazhi
Pang, Tao
Zhao, Jing
Jiao, Jian-peng
Wang, Bin
Liu, Xuan
Xiu, Li-juan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background/Aims.
In previous studies, it has been observed that Xiaotan Jieyu (XTJY) prescription may inhibit the proliferation of human breast precancerous lesion MCF-10AT cells by inhibiting the PI3K/Akt signaling pathway.
The purpose of this study is to further verify the therapeutic effect and the possible mechanism of XTJY on precancerous lesions of breast cancer in vivo.
Methods.
The successfully established breast precancerous lesion rat model and normal healthy rats were randomly assigned into the blank (BLA), model (MOD), XTJY-low (LD), XTJY-medium (MD), XTJY-high (HD), and tamoxifen (TAM) groups.
Different concentrations of XTJY and saline were supplied by intragastric administration for 4 consecutive weeks to assess the protective effect of XTJY on the progress of the breast precancerous lesion in rats involving the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway.
Results.
In this study, it determined that 10 mg/each rat DMBA-combined estrogen and progesterone induction for 10 weeks was the optimal condition for the establishment of the breast precancerous lesion rat model.
In vivo administration of XTJY or TAM was found to inhibit the development of the breast precancerous lesion, and the occurrence rate of breast invasive carcinomas was decreased by about 50%.
Furthermore, XTJY or TAM markedly reduced protein expressions of PI3K and p-Akt and increased protein expressions of PTEN.
Conclusion.
These data indicated that XTJY can significantly alleviate the development of breast precancerous lesions by inhibiting the activation of the PI3K/Akt signaling pathway.
XTJY may be a promising drug for the treatment of precancerous lesions in breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Jing& Pang, Tao& Jiao, Jian-peng& Wang, Bin& Liu, Xuan& Xiu, Li-juan…[et al.]. 2020. Xiaotan Jieyu Prescription Alleviates Breast Precancerous Lesions through PI3KAkt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156058
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Jing…[et al.]. Xiaotan Jieyu Prescription Alleviates Breast Precancerous Lesions through PI3KAkt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156058
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Jing& Pang, Tao& Jiao, Jian-peng& Wang, Bin& Liu, Xuan& Xiu, Li-juan…[et al.]. Xiaotan Jieyu Prescription Alleviates Breast Precancerous Lesions through PI3KAkt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156058
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156058
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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