GEPSI: A Gene Expression Profile Similarity-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula
المؤلفون المشاركون
Wang, Yun
Zhang, Bai-xia
He, Shuaibing
Lv, Chenyang
Zhang, Yanling
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The identification of bioactive components in traditional Chinese medicine (TCM) is an important part of the TCM material foundation research.
Recently, molecular docking technology has been extensively used for the identification of TCM bioactive components.
However, target proteins that are used in molecular docking may not be the actual TCM target.
For this reason, the bioactive components would likely be omitted or incorrect.
To address this problem, this study proposed the GEPSI method that identified the target proteins of TCM based on the similarity of gene expression profiles.
The similarity of the gene expression profiles affected by TCM and small molecular drugs was calculated.
The pharmacological action of TCM may be similar to that of small molecule drugs that have a high similarity score.
Indeed, the target proteins of the small molecule drugs could be considered TCM targets.
Thus, we identified the bioactive components of a TCM by molecular docking and verified the reliability of this method by a literature investigation.
Using the target proteins that TCM actually affected as targets, the identification of the bioactive components was more accurate.
This study provides a fast and effective method for the identification of TCM bioactive components.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Bai-xia& He, Shuaibing& Lv, Chenyang& Zhang, Yanling& Wang, Yun. 2018. GEPSI: A Gene Expression Profile Similarity-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Bai-xia…[et al.]. GEPSI: A Gene Expression Profile Similarity-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Bai-xia& He, Shuaibing& Lv, Chenyang& Zhang, Yanling& Wang, Yun. GEPSI: A Gene Expression Profile Similarity-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر