A Phenolic Fraction from Catharanthus roseus L. Stems Decreases Glycemia and Stimulates Insulin Secretion
المؤلفون المشاركون
Vega-Ávila, Elisa
Espejel-Nava, Janet Alejandra
Contreras-Ramos, Alejandra
Díaz-Rosas, Guadalupe
Trejo-Aguilar, Gloria
Ortega-Camarillo, Clara
Alarcon-Aguilar, Francisco J.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Catharanthus roseus (L.) G.
(C.
roseus) is a medicinal plant used traditionally for diabetes mellitus control.
Several compounds of an alkaloidal nature have been proposed as hypoglycemic principles.
However, little attention has been paid to other compounds in this plant that could also participate in this hypoglycemic activity.
This study aimed to analyze the hypoglycemic effect of a polyphenolic fraction from C.
roseus, as well as its action on insulin secretion and expression in RINm5F cells.
Methods.
An alkaloid-free aqueous extract was obtained from C.
roseus stems.
The hypoglycemic effect of different doses of this extract was evaluated in normal and streptozotocin-induced diabetic mice.
This extract was fractionated by bipartition, and the resultant fractions were assessed by their hypoglycemic effects.
Subsequently, the fraction with the greater hypoglycemic activity was added to the RINm5F cells, and the expression and secretion of insulin were analyzed.
The antioxidant activity was determined by the DPPH method and through chromatographic analysis of the most active fraction by HPLC, using an Econosphere C18 column.
Results.
The aqueous alkaloid-free extract of C.
roseus stems significantly reduced blood glucose in normal and diabetic mice.
The fractionation of this extract provided three fractions, one of which (a precipitate) showed significant reductions in glycemia at 6 h (48.1 and 64.5% in normal and diabetic mice, respectively).
This precipitate contained phenolic compounds and saponins.
Its chromatographic analysis showed that it is formed by several phenolic compounds; gallic acid (0.053%) and chlorogenic acid (0.216%) were identified and quantified.
Conclusion.
The phenolic fraction of C.
roseus containing gallic acid and chlorogenic acid had a hypoglycemic effect that may be explained by an increase in insulin secretion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Espejel-Nava, Janet Alejandra& Vega-Ávila, Elisa& Alarcon-Aguilar, Francisco J.& Contreras-Ramos, Alejandra& Díaz-Rosas, Guadalupe& Trejo-Aguilar, Gloria…[et al.]. 2018. A Phenolic Fraction from Catharanthus roseus L. Stems Decreases Glycemia and Stimulates Insulin Secretion. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Espejel-Nava, Janet Alejandra…[et al.]. A Phenolic Fraction from Catharanthus roseus L. Stems Decreases Glycemia and Stimulates Insulin Secretion. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Espejel-Nava, Janet Alejandra& Vega-Ávila, Elisa& Alarcon-Aguilar, Francisco J.& Contreras-Ramos, Alejandra& Díaz-Rosas, Guadalupe& Trejo-Aguilar, Gloria…[et al.]. A Phenolic Fraction from Catharanthus roseus L. Stems Decreases Glycemia and Stimulates Insulin Secretion. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر