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Shenzhiling Oral Liquid Protects STZ-Injured Oligodendrocyte through PI3KAkt-mTOR Pathway
المؤلفون المشاركون
Wang, Pengwen
Mana, Lulu
Wang, Yahan
Liu, Zhenhong
Qin, Gaofeng
Huang, Shuaiyang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-24
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
White matter degeneration and demyelination are nonnegligible pathological manifestations of Alzheimer’s disease (AD).
The damage of myelin sheath consisting of oligodendrocytes is the basis of AD’s unique early lesions.
Shenzhiling oral liquid (SZL) was the effective Chinese herbal compound approved by the Food and Drug Administration (FDA) for the treatment of AD in China, which plays the exact therapeutic role in clinical AD patients.
However, its molecular mechanism remains unclear to date.
For this purpose, an in vitro mode of streptozotocin- (STZ-) induced rat oligodendrocyte OLN-93 cell injury was established to mimic the pathological changes of myelin sheath of AD and investigate the mechanism of SZL protecting injured OLN-93 cell.
The results showed that STZ can decrease cell viability and downregulate the activity of PI3K/Akt-mTOR signalling pathway and the expression of myelin sheath-related proteins (MBP, MOG, and PLP) in OLN-93 cells.
Both SZL-medicated serum and donepezil (positive control) can protect cells from STZ-caused damage.
SZL-medicated serum increased OLN-93 cell viability in a dose- and time-dependent manner and enhanced the activity of PI3K/Akt-mTOR signalling pathway.
The inhibitor of PI3K (LY294002) inhibited the protective effect of SZL-medicated serum on the STZ-injured OLN-93 cells.
Furthermore, rapamycin, the inhibitor of mTOR, inhibited the promotion of cell viability and upregulation of p-mTOR and MBP caused by SZL-medicated serum.
In conclusion, our data indicate that SZL plays its therapeutic role on AD by promoting PI3K/Akt-mTOR signalling pathway of oligodendrocytes.
Thus, the present study may facilitate the therapeutic research of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Zhenhong& Qin, Gaofeng& Mana, Lulu& Huang, Shuaiyang& Wang, Yahan& Wang, Pengwen. 2020. Shenzhiling Oral Liquid Protects STZ-Injured Oligodendrocyte through PI3KAkt-mTOR Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156176
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Zhenhong…[et al.]. Shenzhiling Oral Liquid Protects STZ-Injured Oligodendrocyte through PI3KAkt-mTOR Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1156176
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Zhenhong& Qin, Gaofeng& Mana, Lulu& Huang, Shuaiyang& Wang, Yahan& Wang, Pengwen. Shenzhiling Oral Liquid Protects STZ-Injured Oligodendrocyte through PI3KAkt-mTOR Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156176
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156176
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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