trans-Cinnamaldehyde Reverses Depressive-Like Behaviors in Chronic Unpredictable Mild Stress Rats by Inhibiting NF-κBNLRP3 Inflammasome Pathway
المؤلفون المشاركون
Wang, Meng
Yan, Shuguang
Zhou, Yongxue
Xie, Pei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-28
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
trans-Cinnamaldehyde (TCA) is the main active component extracted from Cinnamomum cassia (C.
cassia), which has many pharmacological effects, such as anti-inflammation, lowering blood glucose, and improving nerve function.
However, there is no report of TCA in the treatment of depression.
The purpose of this study was to investigate the antidepressant-like effect of TCA and the mechanism of NF kappa B (NF-κB) pathway and NLRP3 inflammasome inhibition by TCA.
We divided 40 rats into the control group, CUMS group, FLU group, and the TCA group.
The activation of the NF-κB pathway and NLRP3 inflammasome in prefrontal cortex and hippocampus of rats in each group was observed.
After the treatments with FLU and TCA, the sucrose consumptions in rats increased significantly and the immobility time in forced swimming was decreased significantly compared to the CUMS group.
The expression of TLR4, NF-κB-1, p-p65, TNF-α, NLRP3, ASC, caspase-1, IL-1β, and IL-18 proteins in prefrontal cortex and hippocampus was decreased, and the expression of IL-1β, IL-18, and TNF-α in serum was downregulated compared to the CUMS group.
Similar to FLU, TCA reverses the depression-like behaviors in rats, which indicates that TCA has a significant antidepressant-like effect.
The mechanism of the antidepressant property of TCA might be that it inhibits the activation of the NF-κB pathway and NLRP3 inflammasome in the prefrontal cortex and hippocampus of CUMS rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Meng& Yan, Shuguang& Zhou, Yongxue& Xie, Pei. 2020. trans-Cinnamaldehyde Reverses Depressive-Like Behaviors in Chronic Unpredictable Mild Stress Rats by Inhibiting NF-κBNLRP3 Inflammasome Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1156198
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Meng…[et al.]. trans-Cinnamaldehyde Reverses Depressive-Like Behaviors in Chronic Unpredictable Mild Stress Rats by Inhibiting NF-κBNLRP3 Inflammasome Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1156198
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Meng& Yan, Shuguang& Zhou, Yongxue& Xie, Pei. trans-Cinnamaldehyde Reverses Depressive-Like Behaviors in Chronic Unpredictable Mild Stress Rats by Inhibiting NF-κBNLRP3 Inflammasome Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1156198
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156198
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر