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YQFM Alleviates Side Effects Caused by Dasatinib through the ROCKMLC Pathway in Mice
المؤلفون المشاركون
Yu, Boyang
Zhang, Yuanyuan
Dai, Yujie
Xu, Han
Liu, Yuankai
Zhou, Qianliu
Kou, Junping
Li, Fang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Dasatinib, as a second-generation broad-spectrum tyrosine kinase inhibitor, presents an antitumor effect by inhibiting tyrosine kinases.
However, dasatinib causes serious side effects, such as gastrointestinal bleeding and liver toxicity, possibly through the activation of ROCK kinase and MLC phosphorylation.
At present, there is no effective prevention and treatment method.
Previous research studies have shown that YQFM (YiQiFuMai powder injection) protects the blood-brain barrier by inhibiting the ROCK/MLC signaling pathway; whether YQFM can alleviate the side effects of dasatinib is unknown.
In this study, dasatinib was injected (i.p.
70 mg/kg) and YQFM (i.p.
0.336 g/kg, 0.672 g/kg, 1.342 g/kg) was given in advance for 3 days to mice, to explore the effect of YQFM on side effects induced by Dasatinib.
The results confirmed that YQFM significantly decreased Evans blue leakage in the small intestine and increased intestinal blood flow, increased the expression of ZO-1, Occludin, and VE-cadherin, and reduced the contents of D-lactic acid, s-VE-cadherin, Alanine aminotransferase (ALT), and Aspartate aminotransferase (AST) in serum.
Finally, YQFM inhibited the expression of ROCK-1 and phosphorylation of MLC induced by Dasatinib.
These findings suggested that YQFM could improve the side effects caused by Dasatinib linked with the ROCK/MLC signaling pathway, as shown in the graphical abstract.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yuankai& Dai, Yujie& Xu, Han& Zhou, Qianliu& Li, Fang& Yu, Boyang…[et al.]. 2020. YQFM Alleviates Side Effects Caused by Dasatinib through the ROCKMLC Pathway in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yuankai…[et al.]. YQFM Alleviates Side Effects Caused by Dasatinib through the ROCKMLC Pathway in Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yuankai& Dai, Yujie& Xu, Han& Zhou, Qianliu& Li, Fang& Yu, Boyang…[et al.]. YQFM Alleviates Side Effects Caused by Dasatinib through the ROCKMLC Pathway in Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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