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Effects of Combined Simultaneous and Sequential Endostar and Cisplatin Treatment in a Mice Model of Gastric Cancer Peritoneal Metastases
المؤلفون المشاركون
Jia, Lin
Ren, Shuguang
Li, Tao
Wu, Jianing
Zhou, Xinliang
Zhang, Yan
Wu, Jianhua
Liu, Wei
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Aimed to study the effects of endostar and cisplatin using an in vivo imaging system (IVIS) in a model of peritoneal metastasis of gastric cancer.
Methods.
NUGC-4 gastric cancer cells transfected with luciferase gene (NUGC-4-Luc) were injected i.p.
into nude mice.
One week later, mice were randomly injected i.p.: group 1, cisplatin (d1–3) + endostar (d4–7); group 2, endostar (d1–4) + cisplatin (d5–7); group 3, endostar + cisplatin d1, 4, and 7; group 4, saline for two weeks.
One week after the final administration, mice were sacrificed.
Bioluminescent data, microvessel density (MVD), and lymphatic vessel density (LVD) were analyzed.
Results.
Among the four groups, there were no significant differences in the weights and in the number of cancer cell photons on days 1 and 8 (P>0.05).
On day 15, the numbers in groups 3 and 1 were less than that in group 2 (P<0.05).
On day 21, group 3 was significantly less than group 2 (P<0.05).
MVD of group 4 was less than that of groups 1 and 2 (P<0.01).
There was no significant difference between groups 2 and 3 (P>0.05) or in LVD number among the four groups (P>0.05).
Conclusions.
IVIS® was more useful than weight, volume of ascites, and number of peritoneal nodules.
The simultaneous group was superior to sequential groups in killing cancer cells and inhibiting vascular endothelium.
Cisplatin-endostar was superior to endostar-cisplatin in killing cancer cells, while the latter in inhibiting peritoneal vascular endothelium.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jia, Lin& Ren, Shuguang& Li, Tao& Wu, Jianing& Zhou, Xinliang& Zhang, Yan…[et al.]. 2017. Effects of Combined Simultaneous and Sequential Endostar and Cisplatin Treatment in a Mice Model of Gastric Cancer Peritoneal Metastases. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156292
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jia, Lin…[et al.]. Effects of Combined Simultaneous and Sequential Endostar and Cisplatin Treatment in a Mice Model of Gastric Cancer Peritoneal Metastases. Gastroenterology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1156292
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jia, Lin& Ren, Shuguang& Li, Tao& Wu, Jianing& Zhou, Xinliang& Zhang, Yan…[et al.]. Effects of Combined Simultaneous and Sequential Endostar and Cisplatin Treatment in a Mice Model of Gastric Cancer Peritoneal Metastases. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156292
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156292
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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