Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1CXCR4 and mSCFKit-ETV1 Pathways in the Stomach of Diabetic Mice
المؤلفون المشاركون
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
The loss of interstitial cells of Cajal (ICC) is observed in diabetic gastroparesis.
Electroacupuncture (EA) maintains ICC networks, but the effects and mechanisms of EA on ICC of bone marrow derivation in the stomach have not been investigated.
Methods.
C57BL/6 mice were randomized into six groups: control, diabetic (DM), bone marrow transplantation (BMT) + DM, BMT + DM + sham EA (SEA), BMT + DM + low-frequency EA (LEA), and BMT + DM + high-frequency (HEA).
c-Kit+GFP+ cells in the stomach were detected by immunofluorescence staining.
Western blotting and qRT-PCR were employed to determine c-Kit, GFP, SDF-1, CXCR4, mSCF, pERK, and ETV1 expression.
Results.
(1) c-Kit+GFP+ cells were elevated in the BMT + DM + LEA and HEA groups.
(2) The mRNA and protein levels of GFP, SDF-1, and CXCR4 were increased in the BMT + DM + LEA and BMT + DM + HEA groups.
(3) The mRNA and protein levels of mSCF, c-Kit, pERK, and ETV1 were significantly reduced in the DM group but markedly elevated in the BMT + DM + LEA and HEA groups.
Conclusion.
EA at ST36 increases bone marrow-derived ICC in the stomach of diabetic mice via the SDF-1/CXCR4 and mSCF/c-Kit-ETV1 pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Jiao& An, Jing& Liu, Shi. 2018. Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1CXCR4 and mSCFKit-ETV1 Pathways in the Stomach of Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156301
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Jiao…[et al.]. Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1CXCR4 and mSCFKit-ETV1 Pathways in the Stomach of Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1156301
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Jiao& An, Jing& Liu, Shi. Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1CXCR4 and mSCFKit-ETV1 Pathways in the Stomach of Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156301
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156301
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر