Deciphering of Key Pharmacological Pathways of Poria Cocos Intervention in Breast Cancer Based on Integrated Pharmacological Method
المؤلفون المشاركون
Wang, Jia
Zhang, Xiaoming
Wu, Jibiao
Liu, Lijuan
Liu, Cun
Sun, Peng
Zhang, Xiaolu
Ma, Xiaoran
Dong, Shixia
Zhuang, Jing
Sun, Changgang
Li, Jie
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Poria cocos (Fuling), a natural plant, has recently emerged as a promising strategy for cancer treatment.
However, the molecular mechanisms of Poria cocos action in breast cancer remain poorly understood.
Methods.
TCMSP database was used to screen the potential active ingredients in Poria cocos.
GEO database was used to identify differentially expressed genes.
Network pharmacology was used to identify the specific pathways and key target proteins related to breast cancer.
Finally, molecular docking was used to validate the results.
Results.
In our study, 237 targets were predicted for 15 potential active ingredients found in Poria cocos.
An interaction network of predicted targets and genes differentially regulated in breast cancers was constructed.
Based on the constructed network and further analysis including network topology, KEGG, survival analysis, and gene set enrichment analysis, 3 primary nodes were identified as key potential targets that were significantly enriched in the PPAR signaling pathway.
Conclusion.
The results showed that potential active ingredients of Poria cocos might interfere with breast cancer through synergistic regulation of PTGS2, ESR1, and FOS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Xiaoran& Wu, Jibiao& Liu, Cun& Li, Jie& Dong, Shixia& Zhang, Xiaolu…[et al.]. 2020. Deciphering of Key Pharmacological Pathways of Poria Cocos Intervention in Breast Cancer Based on Integrated Pharmacological Method. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156324
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Xiaoran…[et al.]. Deciphering of Key Pharmacological Pathways of Poria Cocos Intervention in Breast Cancer Based on Integrated Pharmacological Method. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1156324
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Xiaoran& Wu, Jibiao& Liu, Cun& Li, Jie& Dong, Shixia& Zhang, Xiaolu…[et al.]. Deciphering of Key Pharmacological Pathways of Poria Cocos Intervention in Breast Cancer Based on Integrated Pharmacological Method. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156324
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156324
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر