Metabolic Perturbation and Potential Markers in Patients with Esophageal Cancer

المؤلفون المشاركون

Aa, JiYe
Zhu, Xianlan
Wang, Kun
Liu, Gaoshuang
Wang, Yuqing
Xu, Jin
Liu, Linsheng
Li, Mengjie
Shi, Jian
Yu, Lianzhen

المصدر

Gastroenterology Research and Practice

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-04-20

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض

الملخص EN

Clinical diagnosis of esophageal cancer (EC) at early stage is rather difficult.

This study aimed to profile the molecules in serum and tissue and identify potential biomarkers in patients with EC.

A total of 64 volunteers were recruited, and 83 samples (24 EC serum samples, 21 serum controls, 19 paired EC tissues, and corresponding tumor-adjacent tissues) were analyzed.

The gas chromatography time-of-flight mass spectrometry (GC/TOF-MS) was employed, and principal component analysis was used to reveal the discriminatory metabolites and identify the candidate markers of EC.

A total of 41 in serum and 36 identified compounds in tissues were relevant to the malignant prognosis.

A marked metabolic reprogramming of EC was observed, including enhanced anaerobic glycolysis and glutaminolysis, inhibited tricarboxylic acid (TCA) cycle, and altered lipid metabolism and amino acid turnover.

Based on the potential markers of glucose, glutamic acid, lactic acid, and cholesterol, the receiver operating characteristic (ROC) curves indicated good diagnosis and prognosis of EC.

EC patients showed distinct reprogrammed metabolism involved in glycolysis, TCA cycle, glutaminolysis, and fatty acid metabolism.

The pivotal molecules in the metabolic pathways were suggested as the potential markers to facilitate the early diagnosis of human EC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhu, Xianlan& Wang, Kun& Liu, Gaoshuang& Wang, Yuqing& Xu, Jin& Liu, Linsheng…[et al.]. 2017. Metabolic Perturbation and Potential Markers in Patients with Esophageal Cancer. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156467

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhu, Xianlan…[et al.]. Metabolic Perturbation and Potential Markers in Patients with Esophageal Cancer. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156467

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhu, Xianlan& Wang, Kun& Liu, Gaoshuang& Wang, Yuqing& Xu, Jin& Liu, Linsheng…[et al.]. Metabolic Perturbation and Potential Markers in Patients with Esophageal Cancer. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156467

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1156467