Protective Effects of Grape Seed Proanthocyanidins on the Kidneys of Diabetic Rats through the Nrf2 Signalling Pathway
المؤلفون المشاركون
Ding, Yu-Song
Liu, Tao
Li, Haiyan
Li, Yang
Liu, Dandan
Zhang, Liyuan
Wang, Tongling
Liu, Tao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Diabetic nephropathy (DN) is the most common cause of end-stage renal failure.
Grape seed proanthocyanidin extract (GSPE) is a powerful antioxidant that is believed to protect the kidney through antioxidant action.
However, the underlying mechanism of GSPE protection against DN remains unclear.
Objective.
To explore if GSPE can improve DN by activating nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant response element signalling and to clarify its possible mechanism.
Materials and methods.
Ten healthy Sprague-Dawley rats were randomly selected as controls.
Rats with streptozotocin-induced diabetes were randomly divided into three groups (10 animals/group): type 2 diabetes mellitus (T2DM) group (untreated), L-GSPE group (treated with 125-mg/kg/day GSPE for 8 weeks), and H-GSPE group (treated with 250 mg/kg/day GSPE for 8 weeks).
Results.
Renal histopathological results indicated limited pathological damage in GSPE-treated groups.
Compared with the T2DM group, the H-GSPE group had significantly reduced kidney weight and renal index.
Similarly, the levels of fasting blood glucose, serum creatinine, blood urea nitrogen, uric acid, urinary albumin, and renal malondialdehyde (p<0.05) were also significantly decreased.
In addition, GSPE significantly increased the levels of superoxide dismutase, total antioxidative capability, and glutathione (p<0.05) as well as the protein levels of Nrf2, HO-1, glutathione S-transferase, and NAD (P)H quinone oxidoreductase 1 (p<0.05).
Conclusion.
The results indicate that GSPE reduced renal damage in rats with diabetes by activating the Nrf2 signalling pathway, which consequently increased the antioxidant capacity of the tissue.
Therefore, GSPE is a potential natural agent for the treatment of diabetic nephropathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Yu-Song& Li, Haiyan& Li, Yang& Liu, Dandan& Zhang, Liyuan& Wang, Tongling…[et al.]. 2020. Protective Effects of Grape Seed Proanthocyanidins on the Kidneys of Diabetic Rats through the Nrf2 Signalling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Yu-Song…[et al.]. Protective Effects of Grape Seed Proanthocyanidins on the Kidneys of Diabetic Rats through the Nrf2 Signalling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Yu-Song& Li, Haiyan& Li, Yang& Liu, Dandan& Zhang, Liyuan& Wang, Tongling…[et al.]. Protective Effects of Grape Seed Proanthocyanidins on the Kidneys of Diabetic Rats through the Nrf2 Signalling Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر