Chinese Medicine for Psoriasis Vulgaris Based on Syndrome Pattern: A Network Pharmacological Study
المؤلفون المشاركون
Zhu, Wei
Wang, Dongmei
Lu, Chuanjian
Yu, Jingjie
Zhang, Miaomiao
Gu, Jiangyong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-28
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Background.
The long-term use of conventional therapy for psoriasis vulgaris remains a challenge due to limited or no patient response and severe side effects.
Complementary and alternative treatments such as traditional Chinese medicine (TCM) are widely used in East Asia.
TCM treatment is based on individual syndrome types.
Three TCM formulae, Compound Qingdai Pills (F1), Yujin Yinxie Tablets (F2), and Xiaoyin Tablets (F3), are used for blood heat, blood stasis, and blood dryness type of psoriasis vulgaris, respectively.
Objectives.
To explore the mechanism of three TCM formulae for three syndrome types of psoriasis vulgaris.
Methods.
The compounds of the three TCM formulae were retrieved from the Psoriasis Database of Traditional Chinese Medicine (PDTCM).
Their molecular properties of absorption, distribution, metabolism, excretion and toxicity (ADME/T), and drug-likeness were compared by analyzing the distribution of compounds in the chemical space.
The cellular targets of the compounds were predicted by molecular docking.
By constructing the compound-target network and analyzing network centrality, key targets and compounds for each formula were screened.
Three syndrome types of psoriasis vulgaris related pathways and biological processes (BPs) were enriched by the Database for Annotation, Visualization, and Integrated Discovery (DAVID) v6.8.
Results.
The compounds of the three formulae exhibited structural diversity, good drug-like properties, and ADME/T properties.
A total of 72, 97 and 85 targets were found to have interactions with compounds of F1, F2, and F3, respectively.
The three formulae were all related to 53 targets, 8 pathways, 9 biological processes, and 10 molecular functions (MFs).
In addition, each formula had unique targets and regulated different pathways and BPs.
Conclusion.
The three TCM formulae exhibited common mechanisms to some extent.
The differences at molecular and systems levels may contribute to their unique applications in individualized treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Dongmei& Lu, Chuanjian& Yu, Jingjie& Zhang, Miaomiao& Zhu, Wei& Gu, Jiangyong. 2020. Chinese Medicine for Psoriasis Vulgaris Based on Syndrome Pattern: A Network Pharmacological Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1156479
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Dongmei…[et al.]. Chinese Medicine for Psoriasis Vulgaris Based on Syndrome Pattern: A Network Pharmacological Study. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1156479
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Dongmei& Lu, Chuanjian& Yu, Jingjie& Zhang, Miaomiao& Zhu, Wei& Gu, Jiangyong. Chinese Medicine for Psoriasis Vulgaris Based on Syndrome Pattern: A Network Pharmacological Study. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1156479
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156479
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر