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Anti-inflammatory Mechanism of Ruzu Bitters on Diet-Induced Nonalcoholic Fatty Liver Disease in Male Wistar Rats
المؤلفون المشاركون
Iheagwam, Franklyn Nonso
Ogunlana, Olubanke Olujoke
Ogunlana, Oluseyi E.
Adekunbi, Tobi S.
Adetuyi, Babatunde O.
Adegboye, Bose E.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Nonalcoholic fatty liver disease (NAFLD) has become notorious globally.
Increasingly emerging evidence shows that NAFLD is strongly associated with inflammation, with proinflammatory cytokines such as interleukin-2 (IL-2), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α) playing a vital role in its progression.
In this work, an attempt was made to verify the anti-inflammatory activity of Ruzu herbal bitters (RHB), an antiobesity medicinal concoction, on NAFLD induced by a high-fat diet (HFD) in albino Wistar rats.
Twenty-five (25) rats were divided into five groups as follows: Group 1, the normal control, was maintained on standard rat chow and received normal saline (1 ml/kg body weight (BW)/day) for twelve weeks.
The other groups were maintained on HFD for twelve weeks.
Thereafter, groups 2–5 were treated with pioglitazone (4 mg/kg BW/day), RHB (0.6 ml/kg BW/day), normal saline (1 ml/kg BW/day), and fenofibrate (10 mg/kg BW/day), respectively.
The animals were sacrificed after the experimental period.
Biochemical indicators of oxidative stress and inflammation were assayed in the liver according to standard methods.
The histological features of the liver were also compared to assess liver damage.
RHB significantly (p<0.05) reduced body weight and liver index, inhibited oxidative stress, boosted antioxidant enzymes by increasing the activity and level of SOD and GSH, reduced proinflammatory markers (IL-2, IL-6, TNF-α), and reversed histological alterations induced by NAFLD in rat liver.
In conclusion, the anti-inflammatory activity of RHB in the prevention of NAFLD in rats has been confirmed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ogunlana, Olubanke Olujoke& Ogunlana, Oluseyi E.& Adekunbi, Tobi S.& Adetuyi, Babatunde O.& Adegboye, Bose E.& Iheagwam, Franklyn Nonso. 2020. Anti-inflammatory Mechanism of Ruzu Bitters on Diet-Induced Nonalcoholic Fatty Liver Disease in Male Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156486
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ogunlana, Olubanke Olujoke…[et al.]. Anti-inflammatory Mechanism of Ruzu Bitters on Diet-Induced Nonalcoholic Fatty Liver Disease in Male Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156486
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ogunlana, Olubanke Olujoke& Ogunlana, Oluseyi E.& Adekunbi, Tobi S.& Adetuyi, Babatunde O.& Adegboye, Bose E.& Iheagwam, Franklyn Nonso. Anti-inflammatory Mechanism of Ruzu Bitters on Diet-Induced Nonalcoholic Fatty Liver Disease in Male Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156486
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156486
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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