![](/images/graphics-bg.png)
Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience
المؤلفون المشاركون
Gerken, Guido
Canbay, Ali
Buechter, Matthias
Manka, Paul
Heinemann, Falko Markus
Lindemann, Monika
Juntermanns, Benjamin
Kahraman, Alisan
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited.
However, there might be differences related to the origin.
Patients and Methods.
We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2).
Results.
The majority of patients suffered from AIP1 (55.6%).
AIP1 patients were significantly older than AIP2 patients (54.4 versus 40.8 years).
Moreover, 85.0% of AIP1 patients had concurrent autoimmune cholangitis (AIC) while 18.8% of AIP2 patients suffered from overlap to ulcerative colitis (UC).
However, AIP1 patients revealed a cholestatic course and had significantly higher immunoglobulin G4 levels (IgG4).
When compared to allele frequencies in healthy controls, in patients with AIP1 HLA-B8 reached statistical significance.
Response to steroids was excellent in both groups, but we noticed high rates of relapse especially in AIP1 patients.
Finally, 3 patients with AIP1 were diagnosed with cholangiocellular carcinoma (CCC).
Conclusion.
In contrast to Asian studies, we found an almost equal distribution of AIP1 and AIP2 patients in our German cohort.
AIP2 patients were younger and mostly of female gender whereas AIP1 patients revealed higher IgG4 levels and involvement of the biliary tract in sense of IgG4-associated cholangitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Buechter, Matthias& Manka, Paul& Heinemann, Falko Markus& Lindemann, Monika& Juntermanns, Benjamin& Canbay, Ali…[et al.]. 2017. Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156503
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Buechter, Matthias…[et al.]. Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156503
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Buechter, Matthias& Manka, Paul& Heinemann, Falko Markus& Lindemann, Monika& Juntermanns, Benjamin& Canbay, Ali…[et al.]. Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156503
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156503
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)