Exploring the Mechanism of Danshen against Myelofibrosis by Network Pharmacology and Molecular Docking
المؤلفون المشاركون
Gao, Chundi
Zhuang, Jing
Liu, Lijuan
Li, Huayao
Liu, Cun
Li, Jie
Ma, Xiaoran
Zhou, Chao
Wang, Kejia
Sun, Changgang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Danshen (Salvia miltiorrhiza Bunge), a natural powerful drug for various conditions treatment, has traditionally been used in Asian countries for centuries as anticancer agent, anti-inflammatory agent, and antioxidant.
More recently, it is explored in combination with other herbs for skeletal diseases therapy; bone-targeting compounds with pharmacological activities have been isolated from various sources of traditional Chinese medicine (TCM), including Danshen.
In this case, some evidence supports that Danshen may treat myelofibrosis (MF) by exerting its antitumor effect.
To study the specific mechanism of Danshen in the treatment of MF, we used bioinformatics databases to determine its active ingredients.
Then, identification of target proteins related to MF was made using a network pharmacology analysis platform.
In our results, 20 key active compounds and 457 key targets of Danshen were identified.
In-depth network analysis of the top diseases, functions, and pathways suggested that a common underlying mechanism linked Danshen involvement with MF.
Finally, 5 potential targets were confirmed by the analysis; these 5 targets, as well as 20 previously identified compounds, were subjected to molecular docking experiments.
The results indicated that cryptotanshinone of Danshen may affect MF by acting on the key genes in the JAK-STAT signalling pathway and the TGF-β signalling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jie& Ma, Xiaoran& Liu, Cun& Li, Huayao& Zhuang, Jing& Gao, Chundi…[et al.]. 2018. Exploring the Mechanism of Danshen against Myelofibrosis by Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jie…[et al.]. Exploring the Mechanism of Danshen against Myelofibrosis by Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jie& Ma, Xiaoran& Liu, Cun& Li, Huayao& Zhuang, Jing& Gao, Chundi…[et al.]. Exploring the Mechanism of Danshen against Myelofibrosis by Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر