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Effect of Qufengtongluo Decoction on PI3KAkt Signaling Pathway in the Kidney of Type 2 Diabetes Mellitus Rat (GK Rat) with Diabetic Nephropathy
المؤلفون المشاركون
Huang, Xuemin
Huang, Wei Jun
Fu, Qiang
Xiao, Yong-Hua
Gong, Qing
Wu, Wen-Jing
Shen, Zi-Long
Zhang, Hua
Jia, Xu
Zhang, Ya-Xin
Zhao, Jin-Xi
Wang, Shi-Dong
Jia, Mian
Zhang, Yu-Ting
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Qufengtongluo (QFTL) decoction is an effective treatment for diabetic nephropathy (DN).
However, the underlying molecular mechanism is still unclear.
In this study, we try to investigate whether QFTL decoction acts via inhibiting PI3K/Akt signaling pathway.
Twenty-four GK rats were randomly divided into 3 groups: blank group, sham-operated group, and QFTL group.
After model establishment, rats in QFTL group were given QFTL decoction by gavage, while the rest were given pure water.
During the 8-week intervention, 24 hr urinal protein was measured every 2-3 weeks.
After intervention, kidneys were removed for pathological smear, quantitative real-time PCR, and western blotting to detect expression levels of p-PI3K, p-Akt, PTEN, TGF-β, PI3K mRNA, Akt mRNA, PTEN mRNA, and TGF-β mRNA.
QFTL group showed a slighter degree of renal fibrosis in Masson and PASM staining and a greater reduction of 24 hr urinal protein than blank group.
Compared to blank group, expression levels of p-PI3K, p-Akt, PI3K mRNA, and Akt mRNA were lower in QFTL group, while expression levels of PTEN and PTEN mRNA were higher.
Besides, TGF-β was downregulated by QFTL decoction.
In conclusion, this study suggests that QFTL decoction might inhibit PI3K/Akt signaling pathway via activating PTEN and inhibiting TGF-β.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Wei Jun& Fu, Qiang& Xiao, Yong-Hua& Gong, Qing& Wu, Wen-Jing& Shen, Zi-Long…[et al.]. 2018. Effect of Qufengtongluo Decoction on PI3KAkt Signaling Pathway in the Kidney of Type 2 Diabetes Mellitus Rat (GK Rat) with Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156545
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Wei Jun…[et al.]. Effect of Qufengtongluo Decoction on PI3KAkt Signaling Pathway in the Kidney of Type 2 Diabetes Mellitus Rat (GK Rat) with Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156545
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Wei Jun& Fu, Qiang& Xiao, Yong-Hua& Gong, Qing& Wu, Wen-Jing& Shen, Zi-Long…[et al.]. Effect of Qufengtongluo Decoction on PI3KAkt Signaling Pathway in the Kidney of Type 2 Diabetes Mellitus Rat (GK Rat) with Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156545
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156545
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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