Veronicastrum axillare Alleviates Ethanol-Induced Injury on Gastric Epithelial Cells via Downregulation of the NF-kB Signaling Pathway
المؤلفون المشاركون
Zhao, Weichun
Guo, Yan
Xu, Yan-shan
Chen, Gang
Wang, Dan-yi
Meng, Gui-bin
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We used human gastric epithelial cells (GES-1) line in an ethanol-induced cell damage model to study the protective effect of Veronicastrum axillare and its modulation to NF-κB signal pathway.
The goal was to probe the molecular mechanism of V.
axillare decoction in the prevention of gastric ulcer and therefore provide guidance in the clinical application of V.
axillare on treating injuries from chronic nephritis, pleural effusion, gastric ulcer, and other ailments.
The effects of V.
axillare-loaded serums on cell viability were detected by MTT assays.
Enzyme-linked immunosorbent assay (ELISA) and Real-Time PCR methods were used to analyze the protein and mRNA expression of TNF-α, NF-κB, IκBα, and IKKβ.
The results showed that V.
axillare-loaded serum partially reversed the damaging effects of ethanol and NF-κB activator (phorbol-12-myristate-13-acetate: PMA) and increased cell viability.
The protein and mRNA expressions of TNF-α, NF-κB, IκBα, and IKKβ were significantly upregulated by ethanol and PMA while they were downregulated by V.
axillare-loaded serum.
In summary, V.
axillare-loaded serum has significantly protective effect on GES-1 against ethanol-induced injury.
The protective effect was likely linked to downregulation of TNF-α based NF-κB signal pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Weichun& Xu, Yan-shan& Chen, Gang& Guo, Yan& Wang, Dan-yi& Meng, Gui-bin. 2017. Veronicastrum axillare Alleviates Ethanol-Induced Injury on Gastric Epithelial Cells via Downregulation of the NF-kB Signaling Pathway. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156591
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Weichun…[et al.]. Veronicastrum axillare Alleviates Ethanol-Induced Injury on Gastric Epithelial Cells via Downregulation of the NF-kB Signaling Pathway. Gastroenterology Research and Practice No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1156591
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Weichun& Xu, Yan-shan& Chen, Gang& Guo, Yan& Wang, Dan-yi& Meng, Gui-bin. Veronicastrum axillare Alleviates Ethanol-Induced Injury on Gastric Epithelial Cells via Downregulation of the NF-kB Signaling Pathway. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156591
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156591
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر