Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti-Alzheimer’s Disease Agents
المؤلفون المشاركون
Ali-Shtayeh, Mohammed S.
Jamous, Rana M.
Abu-Zaitoun, Salam Y.
Dudai, Nativ
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Lavandula pubescens Decne (LP) is one of the three Lavandula species growing wildly in the Dead Sea Valley, Palestine.
The products derived from the plant, including the essential oil (EO), have been used in Traditional Arabic Palestinian Herbal Medicine (TAPHM) for centuries as therapeutic agents.
The EO is traditionally believed to have sedative, anti-inflammatory, antiseptic, antidepressive, antiamnesia, and antiobesity properties.
This study was therefore aimed to assess the in vitro bioactivities associated with the LP EO.
The EO was separated by hydrodistillation from the aerial parts of LP plants and analyzed for its antioxidant, antimicrobial, anticholinesterase, and antilipase activities.
GC-MS was used for phytochemical analysis.
The chemical analysis of the EO composition revealed 25 constituents, of which carvacrol (65.27%) was the most abundant.
EO exhibited strong antioxidant (IC50 0.16–0.18 μL/mL), antiacetylcholinesterase (IC50 0.9 μL/mL), antibutyrylcholinesterase (IC50 6.82 μL/mL), and antilipase (IC50 1.08 μL/mL) effects.
The EO also demonstrated high antibacterial activity with the highest susceptibility observed for Staphylococcus aureus with 95.7% inhibition.
The EO was shown to exhibit strong inhibitory activity against Candida albicans (MIC 0.47 μL/mL).
The EO was also shown to possess strong antidermatophyte activity against Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum (EC50 0.05–0.06 μL/mL).
The high antioxidant, enzyme inhibitory, and antimicrobial potentials of the EO can, therefore, be correlated with its high content of monoterpenes, especially carvacrol, as shown by its comparable bioactivities indicators results.
This study provided new insights into the composition and bioactivities of LP EO.
Our finding revealed evidence that LP EO makes a valuable natural source of bioactive molecules showing substantial potential as antioxidant, neuroprotective, antihyperlipidemic, and antimicrobial agents.
This study demonstrates, for the first time, that LP EO might be useful for further investigation aiming at integrative CAM and clinical applications in the management of dermatophytosis, Alzheimer’s disease, and obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali-Shtayeh, Mohammed S.& Abu-Zaitoun, Salam Y.& Dudai, Nativ& Jamous, Rana M.. 2020. Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti-Alzheimer’s Disease Agents. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156646
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali-Shtayeh, Mohammed S.…[et al.]. Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti-Alzheimer’s Disease Agents. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156646
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali-Shtayeh, Mohammed S.& Abu-Zaitoun, Salam Y.& Dudai, Nativ& Jamous, Rana M.. Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti-Alzheimer’s Disease Agents. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156646
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156646
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر