![](/images/graphics-bg.png)
Pentagalloyl Glucose- and Ethyl Gallate-Rich Extract from Maprang Seeds Induce Apoptosis in MCF-7 Breast Cancer Cells through Mitochondria-Mediated Pathway
المؤلفون المشاركون
Kantapan, Jiraporn
Paksee, Siwaphon
Chawapun, Pornthip
Sangthong, Padchanee
Dechsupa, Nathupakorn
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-22
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Bouea macrophylla Griffith, locally known as maprang, has important economic value as a Thai fruit tree.
The maprang seed extract (MPSE) has been shown to exhibit antibacterial and anticancer activities.
However, the bioactive constituents in MPSE and the molecular mechanisms underlying these anticancer activities remain poorly understood.
This study aims to identify the active compounds in MPSE and to investigate the mechanisms involved in MPSE-induced apoptosis in MCF-7 treated cancer cells.
The cytotoxic effect was determined by MTT assay.
The apoptosis induction of MPSE was evaluated in terms of ROS production, mitochondrial membrane potential depolarization, and apoptosis-related gene expression.
The compounds identified by HPLC and LC/MS analysis were pentagalloyl glucose, ethyl gallate, and gallic acid.
MPSE treatment decreased cell proliferation in MCF-7 cells, and MPSE was postulated to induce G2/M phase cell cycle arrest.
MPSE was found to promote intracellular ROS production in MCF-7 treated cells and to also influence the depolarization of mitochondrial membrane potential.
In addition, MPSE treatment can lead to increase in the Bax/Bcl-2 gene expression ratio, suggesting that MPSE-induced apoptosis is mitochondria-dependent pathway.
Our results suggest that natural products obtained from maprang seeds have the potential to target the apoptosis pathway in breast cancer treatments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kantapan, Jiraporn& Paksee, Siwaphon& Chawapun, Pornthip& Sangthong, Padchanee& Dechsupa, Nathupakorn. 2020. Pentagalloyl Glucose- and Ethyl Gallate-Rich Extract from Maprang Seeds Induce Apoptosis in MCF-7 Breast Cancer Cells through Mitochondria-Mediated Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1156648
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kantapan, Jiraporn…[et al.]. Pentagalloyl Glucose- and Ethyl Gallate-Rich Extract from Maprang Seeds Induce Apoptosis in MCF-7 Breast Cancer Cells through Mitochondria-Mediated Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1156648
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kantapan, Jiraporn& Paksee, Siwaphon& Chawapun, Pornthip& Sangthong, Padchanee& Dechsupa, Nathupakorn. Pentagalloyl Glucose- and Ethyl Gallate-Rich Extract from Maprang Seeds Induce Apoptosis in MCF-7 Breast Cancer Cells through Mitochondria-Mediated Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1156648
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156648
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)