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Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis
المؤلف
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1).
Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations.
RTX at various doses was injected intraluminally into isolated ileal segments in anesthetized rats.
After 3 hours, the treated segments were removed and inflammation was assessed.
This acute treatment with RTX resulted in biphasic responses: (1) an increase in inflammation similar to that caused by toxin A and capsaicin at low doses of up to 100 ng RTX and (2) no inflammatory effect of RTX at higher doses (1–100 μg), consistent with a defunctionalizing or neurotoxic effect of RTX at high doses.
Separately, anesthetized rats were treated with RTX enemas and one or four weeks later were challenged with toxin A.
Toxin A-induced colitis was significantly inhibited one week after an RTX enema, and this effect was RTX dose dependent.
When tested four weeks after administration of the RTX enema, protection against toxin A colitis was lost.
In conclusion, an RTX enema protects against toxin A-induced colitis in rats for at least one week but less than four weeks.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vigna, Steven R.. 2017. Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156672
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vigna, Steven R.. Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis. Gastroenterology Research and Practice No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1156672
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vigna, Steven R.. Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156672
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156672
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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