![](/images/graphics-bg.png)
Different Intensity Exercise Preconditions Affect Cardiac Function of Exhausted Rats through Regulating TXNIPTRXNF-ĸBp65NLRP3 Inflammatory Pathways
المؤلفون المشاركون
Ping, Zheng
Xu, Peng
Li, Yuemin
Zhang, Junshi
Yang, Mei
Chang, Yumei
Huang, Heling
Cao, Xuebin
Wang, Yang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To investigate whether exercise preconditioning (EP) improves the rat cardiac dysfunction induced by exhaustive exercise (EE) through regulating NOD-like receptor protein 3 (NLRP3) inflammatory pathways and to confirm which intensity of EP is better.
Method.
Ninety healthy male Sprague Dawley rats were randomly divided into five groups: a control group (CON), exhaustive exercise group (EE), low-, middle-, and high-intensity exercise precondition and exhaustive exercise group (LEP + EE, MEP + EE, HEP + EE group).
We established the experimental model by referring to Bedford’s motion load standard to complete the experiment.
Then, the pathological changes of the myocardium were observed under a light microscope.
Biomarker of myocardial injury in serum and oxidative stress factor in myocardial tissue were evaluated by ELISAs.
The cardiac function parameters were detected using a Millar pressure and volume catheter.
The levels of thioredoxin-interacting protein (TXNIP), thioredoxin protein (TRX), nuclear transcription factor kappa Bp65 (NF-ĸBp65), NLRP3, and cysteinaspartate specific proteinase 1 (Caspase-1) protein in rats’ myocardium were detected by western blotting.
Results.
1.
The myocardial structures of three EP + EE groups were all improved compared with EE groups.
2.
The levels of the creatine phosphating-enzyme MB (CK-MB), reactive oxygen species (ROS), interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor alpha (TNF-α) in three EP + EE groups were all increased compared with CON but decreased compared with the EE group (P<0.05).
3.
Compared with the CON group, slope of end-systolic pressure volume relationship (ESPVR), ejection fraction (EF), and peak rate of the increase in pressure (dP/dtmax) all dropped to the lowest level in the EE group (P<0.05), while the values of cardiac output (CO), stroke volume (SV), end-systolic volume (Ves), end-diastolic volume (Ved), and relaxation time constant (Tau) increased in the EE group (P<0.05).
4.
Compared with the CON group, the expression levels of TXNIP, NF-ĸBp65, NLRP3, and Caspase-1 all increased obviously in the other groups (P<0.05); meanwhile, they were all decreased in three EP + EE groups compared with the EE group (P<0.05).
5.
NLRP3 was positively correlated with heart rate, IL-6, and ROS, but negatively correlated with EF (P<0.01).
Conclusion.
EP protects the heart from EE-induced injury through downregulating TXNIP/TRX/NF-ĸBp65/NLRP3 inflammatory signaling pathways.
Moderate intensity EP has the best protective effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yuemin& Xu, Peng& Wang, Yang& Zhang, Junshi& Yang, Mei& Chang, Yumei…[et al.]. 2020. Different Intensity Exercise Preconditions Affect Cardiac Function of Exhausted Rats through Regulating TXNIPTRXNF-ĸBp65NLRP3 Inflammatory Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156727
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yuemin…[et al.]. Different Intensity Exercise Preconditions Affect Cardiac Function of Exhausted Rats through Regulating TXNIPTRXNF-ĸBp65NLRP3 Inflammatory Pathways. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156727
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yuemin& Xu, Peng& Wang, Yang& Zhang, Junshi& Yang, Mei& Chang, Yumei…[et al.]. Different Intensity Exercise Preconditions Affect Cardiac Function of Exhausted Rats through Regulating TXNIPTRXNF-ĸBp65NLRP3 Inflammatory Pathways. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156727
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156727
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)