Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyogenes-Induced Murine Sinusitis Model
المؤلفون المشاركون
Minami, Masaaki
Makino, Toshiaki
Takase, Hiroshi
Konishi, Toru
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Streptococcus pyogenes (S.
pyogenes) is a species of Gram-positive coccoid bacteria having many virulence factors.
Its capsule and exotoxins can cause upper respiratory tract infections such as sinusitis.
The general treatment for S.
pyogenes-induced sinusitis is administration of antibiotics such as penicillin and macrolides; however, a serious problem associated with these antibiotics is their attenuated effect.
Shin’iseihaito (Xinyiqingfeitang), a formula of Japanese traditional Kampo medicine and traditional Chinese medicine, has been used for the treatment of sinusitis.
In general, formulas of Japanese traditional Kampo medicine are orally administered.
This is in contrast to certain formulas of traditional Chinese medicine, which are being recently administered intramuscularly or intravenously.
Regarding these traditional Chinese medicine formulas, the injection methodology is reported to be more effective than oral intake.
In this study, we compared the efficacy between orally and intramuscularly administered Shin’iseihaito against S.
pyogenes-induced sinusitis.
We evaluated the antibacterial effect of Shin’iseihaito extract (SSHT) against S.
pyogenes by K-B disk diffusion assay.
Furthermore, we investigated the nasal colonization of S.
pyogenes, determined cytokine (TNF-α, IL-1β, and IL-6) levels, and conducted a splenocyte proliferative assay in a murine sinusitis model.
SSHT displayed direct anti-S.
pyogenes activity.
Intramuscular administration of SSHT decreased the nasal colonization of S.
pyogenes compared with oral administration.
Thymidine uptake analysis revealed that the proliferation of splenocytes from S.
pyogenes-infected mice under intramuscular SSHT treatment was upregulated compared to that of splenocytes from S.
pyogenes-infected mice under oral SSHT treatment.
We also found that TNF-α, IL-1β, and IL-6 levels in the nasal discharge from intramuscularly treated S.
pyogenes-infected mice were lower than those from orally treated mice.
Our findings suggest that intramuscular administration of Shin’iseihaito may be useful for the treatment of murine S.
pyogenes-induced sinusitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Minami, Masaaki& Konishi, Toru& Takase, Hiroshi& Makino, Toshiaki. 2018. Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyogenes-Induced Murine Sinusitis Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Minami, Masaaki…[et al.]. Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyogenes-Induced Murine Sinusitis Model. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Minami, Masaaki& Konishi, Toru& Takase, Hiroshi& Makino, Toshiaki. Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyogenes-Induced Murine Sinusitis Model. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر