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Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERKNF-κB Pathway
المؤلفون المشاركون
Lu, Jie
Li, Jingjing
Li, Sainan
Liu, Tong
Yu, Qiang
Feng, Jiao
Wu, Liwei
Lu, Xiya
Zhang, Qinghui
Xu, Shizan
Wang, Wenwen
Fan, Xiaoming
Xia, Yujing
Zhou, Ying-Qun
Chen, Kan
Guo, Chuan-Yong
Weiqi, Dai
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-16
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
Hepatic ischemia reperfusion (IR) injury is a common phenomenon in transplantation or trauma.
The aim of the present study was to determine the protective effect of quercetin (QE) on hepatic IR injury via the ERK/NF-κB pathway.
Methods.
Mice were randomized into the sham, IR, QE100 + IR, and QE200 + IR groups.
Quercetin was administered intragastrically daily at two doses (100 mg/kg and 200 mg/kg) for 5 days prior to IR injury.
The expression levels of liver enzymes, inflammatory cytokines, and other marker proteins were determined at 2, 8, and 24 hours after IR.
And they were compared among these groups.
Results.
Compared with the IR group, the treatment of QE reduced the release of cytokines, leading to inhibition of apoptosis and autophagy via downregulation of the ERK/NF-κB pathway in this model of hepatic IR injury.
Conclusion.
Apoptosis and autophagy caused by hepatic IR injury were inhibited by QE following a reduction in the release of inflammatory cytokines, and the relationship between the two may be associated with inactivation of the ERK/NF-κB pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Liwei& Zhang, Qinghui& Weiqi, Dai& Li, Sainan& Feng, Jiao& Li, Jingjing…[et al.]. 2017. Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERKNF-κB Pathway. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1156757
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Liwei…[et al.]. Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERKNF-κB Pathway. Gastroenterology Research and Practice No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1156757
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Liwei& Zhang, Qinghui& Weiqi, Dai& Li, Sainan& Feng, Jiao& Li, Jingjing…[et al.]. Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERKNF-κB Pathway. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1156757
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156757
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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