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Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines
المؤلفون المشاركون
Sytwu, Huey-Kang
Hsu, Po-Chih
Cheng, Ching-Feng
Hsieh, Po-Chun
Chen, Yi-Hsuan
Kuo, Chan-Yen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Oral cancer belongs to the class of head and neck cancers and can be life threatening if not diagnosed and treated early.
Activation of cell death via apoptosis or reactive oxygen species (ROS) accumulation and inhibition of cell cycle progression, migration, and epithelial-to-mesenchymal transition (EMT) may be a good strategy to arrest the development of oral cancer.
In this study, we analyzed the possible action of chrysophanol isolated from the rhizomes of Rheum palmatum on the oral cancer cell lines FaDu (human pharynx squamous cell carcinoma) and SAS (human tongue squamous carcinoma) by investigating whether chrysophanol could influence cell death.
Method.
Cell viability was measured by using the MTT assay.
For the detection of apoptosis, terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining and subG1 population analysis were used.
We also examined cell cycle progression and ROS levels by flow cytometry.
Additionally, the expression of p53, p21, procaspase 3, cyclin D1, CDK4, cdc2, CDK2, E-cadherin, vimentin, and PCNA was evaluated by western blotting.
Conclusion.
Chrysophanol has an anticancer effect on FaDu and SAS cell lines.
There is an increase in subG1 accumulation, ROS production, and cell cycle G1 arrest after treatment with chrysophanol.
On the other hand, chrysophanol inhibited cell migration/metastasis and EMT.
We proposed that chrysophanol may be a good candidate compound on oral cancer treatment in the further.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsu, Po-Chih& Cheng, Ching-Feng& Hsieh, Po-Chun& Chen, Yi-Hsuan& Kuo, Chan-Yen& Sytwu, Huey-Kang. 2020. Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsu, Po-Chih…[et al.]. Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsu, Po-Chih& Cheng, Ching-Feng& Hsieh, Po-Chun& Chen, Yi-Hsuan& Kuo, Chan-Yen& Sytwu, Huey-Kang. Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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