Antiaging Activity of Peptide Identified from Fermented Trapa Japonica Fruit Extract in Human Dermal Fibroblasts
المؤلفون المشاركون
Jang, Jin Dong
Kim, Minkyung
Nam, Gun-He
Kim, Young-Min
Kang, Sang Moon
Lee, Kee-Young
Park, Young-Joon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We have previously shown that Trapa japonica fruit extract (TJE) as well as its fermented extract (FTJ) can be potentially used to treat alopecia.
In the current study, a newly synthesized peptide (PEP) was detected in an active compound isolated from FTJ.
Several biological assays were conducted to verify the antiaging effects of TJE, FTJ, and PEP on the skin.
We examined the effects of TJE, FTJ, and PEP on cell viability, collagen synthesis, and inhibition of mRNA expression of matrix metalloproteinases (MMPs), induced by tumor necrosis factor alpha (TNF-α), in human dermal fibroblasts (HDFs).
In addition, a wound-healing assay of the human keratinocyte cell line (HaCaT) and a clinical study of antiaging activity were conducted.
The findings confirmed that PEP exerted an effect on cell proliferation in a dose-dependent manner.
Treatment with TJE, FTJ, and PEP increased collagen synthesis but inhibited TNF-α-induced mRNA expression of MMPs.
Compared with TJE and FTJ, PEP promoted a significant level of wound recovery in HaCaT cells and also exhibited antiaging effect, as demonstrated by a clinical study.
These results suggest that PEP shows potential as a skin antiaging cosmetic product.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jang, Jin Dong& Kim, Minkyung& Nam, Gun-He& Kim, Young-Min& Kang, Sang Moon& Lee, Kee-Young…[et al.]. 2020. Antiaging Activity of Peptide Identified from Fermented Trapa Japonica Fruit Extract in Human Dermal Fibroblasts. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156780
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jang, Jin Dong…[et al.]. Antiaging Activity of Peptide Identified from Fermented Trapa Japonica Fruit Extract in Human Dermal Fibroblasts. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156780
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jang, Jin Dong& Kim, Minkyung& Nam, Gun-He& Kim, Young-Min& Kang, Sang Moon& Lee, Kee-Young…[et al.]. Antiaging Activity of Peptide Identified from Fermented Trapa Japonica Fruit Extract in Human Dermal Fibroblasts. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156780
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156780
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر