The Therapeutic Effect of Shugan Xiehuo Formula in the Female Rat Model with Central Precocious Puberty
المؤلفون المشاركون
Yin, Weiping
Li, Songmei
Ma, Dianfei
Shi, Tingting
Xiong, Lei
Xia, Jie
Zhang, Kun
Xu, Yin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Central precocious puberty (CPP) severely affects children’s physical and mental health and needs to be treated promptly and effectively.
This article aimed to research the therapeutic effect of Shugan Xiehuo Formula (SXF) on CPP.
A female CPP rat model was established and then treated with leuprolide and different doses of SXF.
Sex organ volume and index were measured.
Ovaries and uteri were visualized by hematoxylin-eosin staining.
The concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), and estradiol (E2) in peripheral blood were determined.
The expression levels of gonadotropin-releasing hormone (GnRH), gonadotropin-releasing hormone receptor (GnRHR), estrogen receptor alpha (ERα), and G protein-coupled receptor 30 (GPR30) in the hypophysis were investigated by Real-Time Quantitative Reverse Transcription PCR and western blot.
GnRH expression in the hypothalamus and GnRHR expression in the ovary were detected by immunohistochemistry.
SXF reduced the volume of the bilateral ovaries, as well as the volumes of the uterus, hypothalamus, and hypophysis in the female CPP rats and diminished the index of the ovary, uterus, hypothalamus, and hypophysis in the female CPP rats (P<0.05 or P<0.01).
SXF treatment inhibited follicle maturation and uterine wall thickening in the female CPP rats.
SXF decreased the concentrations of FSH, LH, PRL, and E2 in the peripheral blood in the female CPP rats (P<0.01 or P<0.001).
SXF suppressed the expressions of GnRH, GnRHR, ERα, and GPR30 in the hypophysis (P<0.05), the expression of GnRH in the hypothalamus (P<0.01), and the expression of GnRHR in the ovaries (P<0.001) of the female CPP rats.
Overall, our study revealed that SXF had therapeutic effects on CPP in female rats.
This is worthy of promoting clinically.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yin, Weiping& Li, Songmei& Zhang, Kun& Xu, Yin& Ma, Dianfei& Shi, Tingting…[et al.]. 2020. The Therapeutic Effect of Shugan Xiehuo Formula in the Female Rat Model with Central Precocious Puberty. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156783
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yin, Weiping…[et al.]. The Therapeutic Effect of Shugan Xiehuo Formula in the Female Rat Model with Central Precocious Puberty. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156783
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yin, Weiping& Li, Songmei& Zhang, Kun& Xu, Yin& Ma, Dianfei& Shi, Tingting…[et al.]. The Therapeutic Effect of Shugan Xiehuo Formula in the Female Rat Model with Central Precocious Puberty. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156783
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156783
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر