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Effect of Qingxin Kaiqiao Fang on Hippocampus mRNA Expression of the Inflammation-Related Genes IL-1β, GFAP, and Aβ in an Alzheimer’s Disease Rat Model
المؤلفون المشاركون
Wang, Yi-ru
Li, Yan
Lin, Jian-Wei
Hu, Hai-Yan
Mao, Dan-Dan
Yang, Wen-Yu
Gao, Shi-Yu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effects of QKF on expression of amyloid-beta (Aβ), interleukin-1 beta (IL-1β), and glial fibrillary acidic protein (GFAP) using a rat model of AD.
Materials and Methods.
Fifty-six male Sprague-Dawley rats were randomly divided into seven groups (eight rats each): control group, sham-operated group, AD model group, groups of AD rats administered with low, medium, and high doses of QKF, and the donepezil group.
AD was established by bilateral injection of β-amyloid (Aβ) 1–40 into the hippocampus.
Two days after AD was established, drugs were administered by gavage.
After 14 days of treatment, we used RT-PCR, Western blotting, and immunohistochemistry to measure the transcript expression and protein abundance of Aβ, IL-1β, and GFAP, and methenamine silver staining was used to detect amyloid protein particle deposition.
Results.
Compared to the control group, the rats from the AD model group showed significantly greater expression levels of Aβ, IL-1β, and GFAP.
However, these differences in expression were abolished by treatment with QKF or donepezil.
Conclusion.
QKF possesses therapeutic potential against AD because it downregulated Aβ, IL-1β, and GFAP in the hippocampus of AD rats.
Future studies should further examine the mechanisms through which QKF produces its effects and the consequences of long-term QKF administration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mao, Dan-Dan& Yang, Wen-Yu& Li, Yan& Lin, Jian-Wei& Gao, Shi-Yu& Wang, Yi-ru…[et al.]. 2018. Effect of Qingxin Kaiqiao Fang on Hippocampus mRNA Expression of the Inflammation-Related Genes IL-1β, GFAP, and Aβ in an Alzheimer’s Disease Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1156855
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mao, Dan-Dan…[et al.]. Effect of Qingxin Kaiqiao Fang on Hippocampus mRNA Expression of the Inflammation-Related Genes IL-1β, GFAP, and Aβ in an Alzheimer’s Disease Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1156855
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mao, Dan-Dan& Yang, Wen-Yu& Li, Yan& Lin, Jian-Wei& Gao, Shi-Yu& Wang, Yi-ru…[et al.]. Effect of Qingxin Kaiqiao Fang on Hippocampus mRNA Expression of the Inflammation-Related Genes IL-1β, GFAP, and Aβ in an Alzheimer’s Disease Rat Model. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1156855
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156855
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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