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Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs
المؤلفون المشاركون
Yi, Ping
Zou, Xin
Xu, Lijun
Li, Lingli
Peng, Ze
Hu, Qian
Yu, Yan
Huang, Dongmei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-08
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Aim.
To further investigate the mechanism behind the antitumor properties of berberine regarding lipid metabolism.
Methods.
Cell viability, proliferation, and apoptosis assays were performed to determine the antigrowth effects of berberine in vitro.
Ectopic xenograft models in Balb/c nude mice were established to determine the antitumor effects of berberine in vivo.
Results.
Berberine inhibited cell viability and proliferation of MGC803 human gastric cancer cell lines in a time- and dose-dependent manner.
Berberine induced apoptosis of MGC803 and increased the apoptotic rate with higher doses.
Berberine induced the accumulation of fatty acid of MGC803 and suppressed the protein expression of FABPs and PPARα.
The FABP inhibitor BMS309403 recapitulated the effects of berberine on MGC803 cells.
In the xenograft model, berberine significantly decreased the tumor volume and tumor weight and induced apoptosis in tumor tissues.
Berberine significantly elevated the fatty acid content and inhibited the expression of FABPs and PPARα in the MGC803 xenograft models.
Conclusion.
Berberine exerted anticancer effects on human gastric cancer both in vitro and in vivo by inducing apoptosis, which was due to the reduced protein expression of FABPs and the accumulation of fatty acid.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Lingli& Peng, Ze& Hu, Qian& Xu, Lijun& Zou, Xin& Yu, Yan…[et al.]. 2020. Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1156871
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Lingli…[et al.]. Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1156871
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Lingli& Peng, Ze& Hu, Qian& Xu, Lijun& Zou, Xin& Yu, Yan…[et al.]. Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1156871
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156871
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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