The Effect of Sanggua Drink Extract on Insulin Resistance through the PI3KAKT Signaling Pathway
المؤلفون المشاركون
Cai, Yu
Wang, Ying
Zhi, Fei
Xing, Qi-Chang
Chen, Yun-Zhong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Treating type 2 diabetes mellitus (T2DM) using thiazolidinediones and biguanides can present several challenges for patients.
Sanggua Drink (SGD) is a commonly used agent in traditional Chinese medicine, and it consists of Folium Mori, Fructus Momordicae Charantiae, Radix Puerariae Lobatae, and Rhizoma Dioscorea.
The hypoglycemic effects and mechanisms of SGD extracts on insulin resistance in diabetic rats were investigated.
SGD (1.24 g/kg orally) was verified in T2DM rats induced by a high-fat diet and streptozotocin.
The results showed that SGD treatment was observed to reduce fasting blood glucose, water and food intake, total cholesterol triglycerides, and LDL, OGTT, FINS, HOMA-IR, GHb, and MDA and increase hepatic glycogen, HDL, SOD, CAT, and GSH-Px in diabetic rats.
Simultaneously, SGD treatment by T2DM showed significantly ameliorated pathological changes and reduced inflammation in the pancreas.
Treatment was also observed to increase gene and protein expressions of InsR, IRS-2, PI3K, AKT, and Glut4 in the livers of diabetic treated rats.
These results suggest that SGD extracts have hypoglycemic properties and may alleviate insulin resistance in T2DM rats through the PI3K/AKT pathway.
Therefore, SGD appears to be a promising insulin sensitizer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Yu& Wang, Ying& Zhi, Fei& Xing, Qi-Chang& Chen, Yun-Zhong. 2018. The Effect of Sanggua Drink Extract on Insulin Resistance through the PI3KAKT Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156891
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Yu…[et al.]. The Effect of Sanggua Drink Extract on Insulin Resistance through the PI3KAKT Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156891
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Yu& Wang, Ying& Zhi, Fei& Xing, Qi-Chang& Chen, Yun-Zhong. The Effect of Sanggua Drink Extract on Insulin Resistance through the PI3KAKT Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156891
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156891
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر