Polyphenol Extract of Moringa Oleifera Leaves Alleviates Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice
المؤلفون المشاركون
Ai, Yu
Peng, Lei
Xie, Jing
Zhang, Yunjuan
Li, Wenyun
Dai, Tianyi
Nie, Long
Li, Lingfei
Tian, Yang
Sheng, Jun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Moringa oleifera Lam.
is an essential herb used for the treatment of inflammation, diabetes, high blood pressure, and other diseases.
In this study, phenolic extracts of M.
oleifera leaves were obtained and analyzed.
The results showed that the main identifiable phenols were astragalin, chlorogenic acid, isoquercitrin, kaempferitrin, luteolin, quercetin, and rutin.
The effects of M.
oleifera polyphenol extract (MOPE) on experimental colitis induced by 3% dextran sulfate sodium (DSS) were investigated.
The results showed that oral administration of MOPE significantly alleviated the symptoms of DSS-induced colitis.
MOPE significantly reduced weight loss, the disease activity index, colon shortening, and mucosal damage.
In addition, MOPE attenuated the infiltration of CD3+ T cells, CD177+ neutrophils, and F4/80+ macrophages and significantly inhibited the secretion of IL-6 and TNF-α.
After the MOPE administration, the expression of proteins associated with the NF-κB signaling pathway changed.
Specifically, compared with that of the DSS group, the protein expression of NF-κB p65 and p-IκBα was downregulated, and the expression of IκBα was upregulated.
This study revealed the anti-inflammatory effects and mechanisms of MOPE in the colon, indicating its potential use in preventing inflammation-driven diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yunjuan& Peng, Lei& Li, Wenyun& Dai, Tianyi& Nie, Long& Xie, Jing…[et al.]. 2020. Polyphenol Extract of Moringa Oleifera Leaves Alleviates Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156893
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yunjuan…[et al.]. Polyphenol Extract of Moringa Oleifera Leaves Alleviates Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156893
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yunjuan& Peng, Lei& Li, Wenyun& Dai, Tianyi& Nie, Long& Xie, Jing…[et al.]. Polyphenol Extract of Moringa Oleifera Leaves Alleviates Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156893
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156893
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر