Squalene Stimulates a Key Innate Immune Cell to Foster Wound Healing and Tissue Repair
المؤلفون المشاركون
Sánchez-Quesada, Cristina
López-Biedma, Alicia
Gaforio, José J.
Toledo, Estefania
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Anti-inflammatory effects of virgin olive oil (VOO) have been described recently, along with its wound healing effect.
One of the main minor compounds found in VOO is squalene (SQ), which also possesses preventive effects against skin damage and anti-inflammatory properties.
The inflammatory response is involved in wound healing and manages the whole process by macrophages, among others, as the main innate cells with a critical role in the promotion and resolution of inflammation for tissue repair.
Because of that, this work is claimed to describe the role that squalene exerts in the immunomodulation of M1 proinflammatory macrophages, which are the first cells implicate in recent injuries.
Pro- and anti-inflammatory cytokines were analysed using TPH1 cell experimental model.
SQ induced an increase in the synthesis of anti-inflammatory cytokines, such as IL-10, IL-13, and IL-4, and a decrease in proinflammatory signals, such as TNF-α and NF-κB in M1 proinflammatory macrophages.
Furthermore, SQ enhanced remodelling and repairing signals (TIMP-2) and recruitment signals of eosinophils and neutrophils, responsible for phagocytosis processes.
These results suggest that SQ is able to promote wound healing by driving macrophage response in inflammation.
Therefore, squalene could be useful at the resolution stage of wound healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sánchez-Quesada, Cristina& López-Biedma, Alicia& Toledo, Estefania& Gaforio, José J.. 2018. Squalene Stimulates a Key Innate Immune Cell to Foster Wound Healing and Tissue Repair. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156905
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sánchez-Quesada, Cristina…[et al.]. Squalene Stimulates a Key Innate Immune Cell to Foster Wound Healing and Tissue Repair. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156905
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sánchez-Quesada, Cristina& López-Biedma, Alicia& Toledo, Estefania& Gaforio, José J.. Squalene Stimulates a Key Innate Immune Cell to Foster Wound Healing and Tissue Repair. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156905
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156905
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر