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A Comparison Study of Chaihu Shugan San and Fluoxetine on Antidepression and Regulating Blood Rheology Effects with Chronic Restrained Stress Rats
المؤلفون المشاركون
Qian, Meng
Peng, Rongyan
Yue, Chen
Yang, Zongchun
Zhu, Haoru
Liu, Biyuan
Xie, Ming
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-12
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Chaihu Shugan San (CHSGS) is a traditional Chinese herbal formula that is often used in clinical practice to treat live Qi stagnation syndrome and depression.
Fluoxetine is one of the commonly used drugs for the clinical treatment of depression.
This study involved a comparison of CHSGS and fluoxetine on antidepression and regulating blood rheology effects with chronic restraint stress- (CRS-) induced depression rat models.
Rats were induced depression models by CRS for 4 weeks.
Upon successful induction of depression in the rats, the animal was administered CHSGS at 0.6 g/kg/d, 1.2 g/kg/d, or fluoxetine 1.8 mg/kg/d to corresponding groups by gavage for 2 weeks.
The changes of CRS rats were determined by behavior observations and sucrose preference test and hypothalamic-pituitary-adrenal cortex (HPA) axis functional status.
The changes in monoamine neurotransmitters and related indicators of blood status were detected by enzyme-linked immunosorbent assay (ELISA), blood rheometer, and other methods.
The outcome shows that CHSGS is superior to fluoxetine in regulating the appearance and HPA axis function of model rats.
In addition, CHSGS and fluoxetine have similar effects in improving blood rheology, and both can alleviate the hypercoagulable state of blood via the platelet 5-hydroxytryptamine receptor 2A (5-HT2A) pathway in rats of depression.
It was also observed that CHSGS can improve the blood state of depressed rats by restoring liver coagulation-anticoagulation balance and endothelium-related functions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qian, Meng& Peng, Rongyan& Yue, Chen& Yang, Zongchun& Zhu, Haoru& Liu, Biyuan…[et al.]. 2020. A Comparison Study of Chaihu Shugan San and Fluoxetine on Antidepression and Regulating Blood Rheology Effects with Chronic Restrained Stress Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1156939
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qian, Meng…[et al.]. A Comparison Study of Chaihu Shugan San and Fluoxetine on Antidepression and Regulating Blood Rheology Effects with Chronic Restrained Stress Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1156939
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qian, Meng& Peng, Rongyan& Yue, Chen& Yang, Zongchun& Zhu, Haoru& Liu, Biyuan…[et al.]. A Comparison Study of Chaihu Shugan San and Fluoxetine on Antidepression and Regulating Blood Rheology Effects with Chronic Restrained Stress Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1156939
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156939
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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