Antihypertensive Activity of Eucommia Ulmoides Oliv: Male Flower Extract in Spontaneously Hypertensive Rats
المؤلفون المشاركون
Ding, Zhen-Jiang
Liang, Chao
Wang, Xiao
Yao, Xin
Yang, Ruo-Han
Zhang, Zhan-Sheng
He, Jin-Jin
Du, Hong-Yan
Fang, Dong
Li, Qin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Eucommia ulmoides Oliv.
is a traditional medical plant in Asia; however, it is still unknown whether Eucommia male flowers have an antihypertensive activity.
In this study, we found that the aqueous extract of Eucommia ulmoides Oliv.
male flowers can lower the blood pressure of SHR in a dose-dependent manner.
Mechanistic studies suggested that the aqueous extract of male flowers can promote the mRNA and protein expressions of ACE2 in the kidney of SHR.
ELISA assay showed that the plasma levels of ANG II was decreased, while ANG-(1–7) was increased in SHR treated with the aqueous extract of male flowers.
ACE2 inhibitor DX600 can reverse the aqueous extract of Eucommia ulmoides Oliv.
male flower-induced downregulation of Ang II and upregulation of Ang-(1–7), as well as the reduction of blood pressure in SHR.
Moreover, Ang-(1–7)-Mas receptor antagonist A-779 abolished the antihypertensive effects of the aqueous extract of Eucommia ulmoides Oliv.
male flower in SHR.
The aqueous extract of Eucommia ulmoides Oliv.
male flowers exhibited an antihypertensive action through the activation of ACE2-Ang-(1–7)-Mas signaling pathways in spontaneously hypertensive rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Zhen-Jiang& Liang, Chao& Wang, Xiao& Yao, Xin& Yang, Ruo-Han& Zhang, Zhan-Sheng…[et al.]. 2020. Antihypertensive Activity of Eucommia Ulmoides Oliv: Male Flower Extract in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1156942
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Zhen-Jiang…[et al.]. Antihypertensive Activity of Eucommia Ulmoides Oliv: Male Flower Extract in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1156942
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Zhen-Jiang& Liang, Chao& Wang, Xiao& Yao, Xin& Yang, Ruo-Han& Zhang, Zhan-Sheng…[et al.]. Antihypertensive Activity of Eucommia Ulmoides Oliv: Male Flower Extract in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1156942
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156942
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر