Traditional Chinese Patent Medicine for Primary Hypertension: A Bayesian Network Meta-Analysis
المؤلفون المشاركون
Zhang, Junhua
Liu, Chunxiang
Tan, Lizi
Shi, Qingyang
Chen, Zhe
Peng, Yingying
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-25
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Background.
Traditional Chinese Patent Medicine (TCPM) is now being used more and more extensively for primary hypertension in China.
However, the comparative efficacy and safety of it need more clarified evidence.
Thus, we conducted a Bayesian network meta-analysis to compare TCPMs with other interventions.
Methods.
We searched China National Knowledge Infrastructure (CNKI), WanFang Data, PubMed, Embase, and Cochrane Library from inception to April 2019 for randomized controlled trials (RCTs) with diagnosis of primary hypertension that compared the efficacy of TCPMs with antihypertension drugs (ADs).
Two researchers screened literature, extracted data, and evaluated risk of bias independently.
The primary outcomes were systolic blood pressure (SBP) and diastolic blood pressure (DBP).
The secondary outcomes were adverse effects (AEs), total cholesterol (TC), and triglyceride (TG).
We used the Bayesian network meta-analysis to compare interventions and described the categorical variable and the continuous variable as odds ratio (OR) and mean difference (MD), respectively.
Besides, we ranked all interventions via the Surface Under the Cumulative Ranking (SUCRA) values and conducted metaregression with nine covariates as additional analysis.
Results.
We included 192 studies with 23366 patients diagnosed as primary hypertension in total.
For SBP reduction, eighteen interventions were significantly better than AD.
Among them, Yinxingye (YXY) + AD (MD = −12, 95% CrI [−16, −8.5]) was superior to others in the rank plot with SUCRA 0.91.
For DBP reduction, sixteen interventions were significantly better than AD.
Among them, Qinggan Jiangya (QGJY) + AD (MD = −8.7, 95% CrI [−12, −5.5]) and Qiju Dihuang (QJDH) + AD (MD = −8.8, 95% CrI [−12, −5.2]) were superior to others in the rank plot with SUCRA 0.89.
To summarize the SUCRA values, we found that QGJY + AD and YXY + AD had the most significant reductions for both SBP and DBP.
YXY + AD was the best one for both TC (MD = −1.3, 95% CrI [−1.9, −0.64]) and TG (MD = −0.52, 95% CrI [−0.92, −0.11]) reductions.
Considering adverse effects, we found two interventions had significant differences comparing with AD.
Among them, YXY + AD was the best one with SUCRA of 0.01.
Conclusion.
In all TCPMs, QGJY + AD and YXY + AD may be the best options for hypertension.
Meanwhile, YXY + AD can improve blood lipids in patients with hypertension.
However, due to the vague reports of adverse effects and other limitations, more evidence, especially that provided by high-quality studies, is needed to prove the advantages of TCMPs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Zhe& Shi, Qingyang& Tan, Lizi& Peng, Yingying& Liu, Chunxiang& Zhang, Junhua. 2020. Traditional Chinese Patent Medicine for Primary Hypertension: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1157039
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Zhe…[et al.]. Traditional Chinese Patent Medicine for Primary Hypertension: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1157039
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Zhe& Shi, Qingyang& Tan, Lizi& Peng, Yingying& Liu, Chunxiang& Zhang, Junhua. Traditional Chinese Patent Medicine for Primary Hypertension: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1157039
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157039
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر