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A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio-Cerebral Vascular Diseases
المؤلفون المشاركون
Huang, Shao-jie
Li, Fei
Wang, Wen-jun
Lei, Lu
Ma, Yang
Yang, Jiani
Zhang, Sha
Li, Zhe
Wang, Kai
Ding, Yi
Wen, Ai-dong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-05
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Objective.
This study is aimed to analyze the active ingredients, drug targets, and related pathways in the combination of Salvia miltiorrhiza (SM) and Radix puerariae (RP) in the treatment of cardio-cerebral vascular diseases (CCVDs).
Method.
The ingredients and targets of SM and RP were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the disease targets were obtained from Therapeutic Target Database (TTD), National Center for Biotechnology Information (NCBI), and Online Mendelian Inheritance in Man (OMIM) Database.
The synergistic mechanisms of the SM and RP were evaluated by gene ontology (GO) enrichment analyses and Kyoto encyclopedia of genes and genomes (KEGG) path enrichment analyses.
Result.
A total of 61 active ingredients and 58 common targets were identified in this study.
KEGG pathway enrichment analysis results showed that SM- and RP-regulated pathways were mainly inflammatory processes, immunosuppression, and cardiovascular systems.
The component-target-pathway network indicated that SM and RP exert a synergistic mechanism for CCVDs through PTGS2 target in PI3k-Akt, TNF, and Jak-STAT signaling pathways.
Conclusion.
In summary, this study clarified the synergistic mechanisms of SM and RP, which can provide a better understanding of effect in the treatment of CCVDs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Yang& Wang, Wen-jun& Yang, Jiani& Zhang, Sha& Li, Zhe& Li, Fei…[et al.]. 2020. A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio-Cerebral Vascular Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1157121
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Yang…[et al.]. A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio-Cerebral Vascular Diseases. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1157121
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Yang& Wang, Wen-jun& Yang, Jiani& Zhang, Sha& Li, Zhe& Li, Fei…[et al.]. A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio-Cerebral Vascular Diseases. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1157121
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157121
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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