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Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation
المؤلفون المشاركون
Anton, Nicolas
Vandamme, Thierry
Halwani, Majed A.
Vassallo, Antonio
Omran, Ziad
Bader, Ammar
Porta, Amalia
Alehaideb, Zeyad
El-Said, Hamdi
Faidah, Hani
Essa, Abulrahman
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The prevalence of nosocomial infections due to multidrug resistant (MDR) bacterial strains is associated with high morbidity and mortality.
Folk medicine and ethnopharmacological data can provide a broad range of plants with promising antimicrobial activity.
Triphala, an Ayurvedic formula composed of three different plants: Terminalia chebula Retz., Terminalia bellirica (Gaertn.) Roxb.
(Combretaceae), and Phyllanthus emblica L.
(Phyllanthaceae), is used widely for various microbial infections.
Various extraction techniques were applied in the extraction of the biologically active constituents of Triphala in order to compare their efficiency.
Microwave-assisted extraction (MAE) was shown to be the most efficient method based on yield, extraction time, and selectivity.
The Triphala hydroalcoholic extract (TAE) has been chemically characterized with spectroscopic and chromatographic techniques.
Triphala hydroalcoholic extract was evaluated alone or with carvacrol.
Different drug formulations including cream and nanoemulsion hydrogel were prepared to assess the antimicrobial activity against selected microorganism strains including Gram-positive and Gram-negative bacteria and fungi.
We used a lipophilic oil of carvacrol (5 mg/mL) and a hydrophilic TAE (5 mg/mL) ingredient in a dosage form.
Two solutions were created: hydrogel containing nanoemulsion as a lipophilic vector dispersed in the gel as a hydrophilic vehicle and a cream formulation, an oil-in-water emulsion.
In both cases, the concentration was 250 mg of active ingredient in 50 mL of final formulation.
The formulas developed were stable from a physical and chemical perspective.
In the nanoemulsion hydrogel, the oil droplet size ranged from 124 to 129 nm, with low polydispersity index (PdI) 0.132 ± 0.013 and negative zeta potential −46.4 ± 4.3 mV.
For the cream, the consistency factor (cetyl alcohol and white wax) induced immobilization of the matrix structure and the stability.
Triphala hydroalcoholic extract in drug nanoformulation illustrated might be an adjuvant antimicrobial agent for treating various microbial infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Omran, Ziad& Bader, Ammar& Porta, Amalia& Vandamme, Thierry& Anton, Nicolas& Alehaideb, Zeyad…[et al.]. 2020. Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157137
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Omran, Ziad…[et al.]. Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1157137
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Omran, Ziad& Bader, Ammar& Porta, Amalia& Vandamme, Thierry& Anton, Nicolas& Alehaideb, Zeyad…[et al.]. Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157137
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157137
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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