A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids
المؤلفون المشاركون
Ma, Xiao
Pan, Xiaoqi
Jiang, Yinxiao
Wen, Jianxia
Yang, Lian
Chen, Dayi
Cao, Xiaoyu
Peng, Cheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-05
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Liver fibrosis resulting from continuous long-term hepatic damage represents a heavy burden worldwide.
Liver fibrosis is recognized as a complicated pathogenic mechanism with extracellular matrix (ECM) accumulation and hepatic stellate cell (HSC) activation.
A series of drugs demonstrate significant antifibrotic activity in vitro and in vivo.
No specific agents with ideally clinical efficacy for liver fibrosis treatment have been developed.
In this review, we summarized the antifibrotic effects and molecular mechanisms of 29 kinds of common natural products.
The mechanism of these compounds is correlated with anti-inflammatory, antiapoptotic, and antifibrotic activities.
Moreover, parenchymal hepatic cell survival, HSC deactivation, and ECM degradation by interfering with multiple targets and signaling pathways are also involved in the antifibrotic effects of these compounds.
However, there remain two bottlenecks for clinical breakthroughs.
The low bioavailability of natural products should be improved, and the combined application of two or more compounds should be investigated for more prominent pharmacological effects.
In summary, exploration on natural products against liver fibrosis is becoming increasingly extensive.
Therefore, natural products are potential resources for the development of agents to treat liver fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Xiaoqi& Ma, Xiao& Jiang, Yinxiao& Wen, Jianxia& Yang, Lian& Chen, Dayi…[et al.]. 2020. A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1157176
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Xiaoqi…[et al.]. A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1157176
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Xiaoqi& Ma, Xiao& Jiang, Yinxiao& Wen, Jianxia& Yang, Lian& Chen, Dayi…[et al.]. A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1157176
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157176
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر