Cordyceps cicadae Prevents Renal Tubular Epithelial Cell Apoptosis by Regulating the SIRT1p53 Pathway in Hypertensive Renal Injury
المؤلفون المشاركون
Xia, Chen Hui
Han, Xue Ting
Zhu, Ze Bing
Cui, Hai Lan
Liu, Yu Ning
Liu, Wei Jing
Feng, Zhendong
Huang, Yi Shan
Wang, Xu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-13
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Hypertensive renal injury is a primary etiology of end-stage renal disease, and satisfactory therapeutic strategies are urgently required.
Cordyceps cicadae, a traditional Chinese herb, has potential renoprotective benefits and is widely used in the treatment of many kidney diseases.
To investigate the mechanisms underlying the renoprotective effect of C.
cicadae on hypertensive renal injury, we studied the effect of C.
cicadae on tubular epithelial cells (TECs) in a spontaneously hypertensive rat (SHR) model and angiotensin II- (AngII-) cultured primary TECs.
Our study showed that C.
cicadae treatment could decrease 24-hour urine albumin, albumin-to-creatinine ratio (ACR), β2-MG level, and kidney injury molecule-1 (kim-1) level in SHR urine, alleviate interstitial fibrosis, and reduce α-smooth muscle actin (α-SMA) expression in SHR kidney.
In primary TECs, medicated serum containing C.
cicadae (CSM) might significantly reduce the AngII-induced production of kim-1 and neutrophil gelatinase-associated lipocalin (NGAL).
Furthermore, C.
cicadae treatment could decrease TEC apoptosis in SHRs as assessed by the terminal transferase-mediated biotin dUTP nick-end labeling (TUNEL) assay.
CSM could inhibit caspase-3 activity and enhance cellular viability as measured by methyl thiazolyl tetrazolium in AngII-cultured TECs, suggesting that CSM might reduce the apoptosis level in TECs induced by AngII.
We found that the SIRT1 expression level was markedly lowered, while the protein level of acetylated-p53 was elevated in the TECs of patients with hypertensive renal injury and SHRs.
C.
cicadae presented the effect of regulating the SIRT1/p53 pathway.
Further SIRT1 inhibition with EX527 reversed the effect of C.
cicadae on AngII-induced apoptosis.
Taken together, our results indicate that C.
cicadae offers a protective effect on TECs under hypertensive conditions, which may be related to its antiapoptotic effect through regulation of the SIRT1/p53 pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Yi Shan& Wang, Xu& Feng, Zhendong& Cui, Hai Lan& Zhu, Ze Bing& Xia, Chen Hui…[et al.]. 2020. Cordyceps cicadae Prevents Renal Tubular Epithelial Cell Apoptosis by Regulating the SIRT1p53 Pathway in Hypertensive Renal Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1157191
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Yi Shan…[et al.]. Cordyceps cicadae Prevents Renal Tubular Epithelial Cell Apoptosis by Regulating the SIRT1p53 Pathway in Hypertensive Renal Injury. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1157191
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Yi Shan& Wang, Xu& Feng, Zhendong& Cui, Hai Lan& Zhu, Ze Bing& Xia, Chen Hui…[et al.]. Cordyceps cicadae Prevents Renal Tubular Epithelial Cell Apoptosis by Regulating the SIRT1p53 Pathway in Hypertensive Renal Injury. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1157191
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157191
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر