Interaction of Cyclooxygenase-2 with Helicobacter pylori Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in Helicobacter pylori-Related Gastric Diseases
المؤلفون المشاركون
Dai, Yunkai
Zhang, Yunzhan
Li, Danyan
Ye, Jintong
Chen, Weijing
Hu, Ling
Chen, Xu
Gong, Lin
Luo, Qi
Chen, Bin
Lan, Shao-yang
Wu, Jian-yu
Zhang, Zi-jing
Huang, Meng-xin
Li, Ru-liu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Cyclooxygenase-2 (COX-2) is an inducible enzyme stimulated by various inflammatory factors (IFs).
Chronic gastritis is a classic model of “inflammation-cancer transformation” and Helicobacter pylori-related gastric diseases (HPGD) are specific ones of this model.
Traditional Chinese Medicine (TCM) syndromes could play a predictive role in gastric histopathological evolution.
To search for early warning evidence about “inflammation-cancer transformation,” this study is about to explore interaction of COX-2 with Helicobacter pylori (Hp) in HPGD with different TCM syndromes.
All included subjects underwent endoscopy and biopsy.
Hp infection was detected by rapid urease test and methylene blue staining.
Histopathological characteristics and COX-2 expression in gastric mucosa (GM) were, respectively, observed by hematoxylin-eosin and Elivision™ plus.
SPSS 18.0 and Stata 11.0 statistical software packages were used for statistical analysis.
Results of immunohistochemical staining in this study showed COX-2 expression in Hp-positive patients was stronger than that in Hp-negative ones.
Spearman’ analysis indicated that degrees of both Hp infection and COX-2 expression were positively correlated with those of gastric inflammation and inflammatory activity.
Compared with the relative normal group, both severe dysplasia group and gastric carcinoma group had more severe Hp infection and COX-2 expression.
Compared with the nonsyndrome, syndrome of internal block of static blood (IBSB) had higher scores in semiquantitative analysis of COX-2 protein expression among TCM groups.
Moreover, multivariate logistics regression analysis suggested that patients with Hp infection could increase the risk of IBSB.
These results indicated that COX-2 interacting with Hp could play an important role in transforming gastric chronic nonresolving inflammation into carcinoma in subjects with HPGD, as well as inducing the formation of IBSB.
HPGD together with IBSB could be an early warning evidence for GM with histopathological evolution from benign to malignant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dai, Yunkai& Zhang, Yunzhan& Li, Danyan& Chen, Xu& Gong, Lin& Luo, Qi…[et al.]. 2020. Interaction of Cyclooxygenase-2 with Helicobacter pylori Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in Helicobacter pylori-Related Gastric Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157218
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dai, Yunkai…[et al.]. Interaction of Cyclooxygenase-2 with Helicobacter pylori Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in Helicobacter pylori-Related Gastric Diseases. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1157218
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dai, Yunkai& Zhang, Yunzhan& Li, Danyan& Chen, Xu& Gong, Lin& Luo, Qi…[et al.]. Interaction of Cyclooxygenase-2 with Helicobacter pylori Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in Helicobacter pylori-Related Gastric Diseases. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157218
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157218
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر