Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19

المؤلفون المشاركون

Cui, Haiming
Wu, Zonggui
Fan, Min
Wu, Feng
Niu, Wenhao
Cao, Wenyue
Chao, YuChieh
Liang, Chun

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-11-05

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الطب البشري

الملخص EN

“Three formulas and three medicines,” which include Jinhua Qinggan granule, Lianhua Qingwen capsule/granule, Xuebijing injection, Qingfei Paidu decoction, HuaShiBaiDu formula, and XuanFeiBaiDu granule, have been proven to be effective in curbing coronavirus disease 2019 (COVID-19), according to the State Administration of Traditional Chinese Medicine.

The aims of this study were to identify the active components of “Three formulas and three medicines” that can be used to treat COVID-19, determine their mechanism of action via angiotensin-converting enzyme 2 (ACE2) by integrating network pharmacological approaches, and confirm the most effective components for COVID-19 treatment or prevention.

We investigated all the compounds present in the aforementioned herbal ingredients.

Compounds that could downregulate the transcription factors (TFs) of ACE2 and upregulate miRNAs of ACE2 were screened via a network pharmacology approach.

Hepatocyte nuclear factor 4 alpha (HNF4A), peroxisome proliferator-activated receptor gamma (PPARG), hsa-miR-2113, and hsa-miR-421 were found to regulate ACE2.

Several compounds, such as quercetin, decreased ACE2 expression by regulating the aforementioned TFs or miRNAs.

After comparison with the compounds present in Glycyrrhiza Radix et Rhizoma, quercetin, glabridin, and gallic acid present in the herbal formulas and medicines were found to alter ACE2 expression.

Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were used to search for possible molecular mechanisms of these compounds.

In conclusion, traditional Chinese medicine (TCM) plays a pivotal role in the prevention and treatment of COVID-19.

Quercetin, glabridin, and gallic acid, the active components of recommended TCM formulas and medicines, can inhibit COVID-19 by downregulating ACE2.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Niu, Wenhao& Wu, Feng& Cui, Haiming& Cao, Wenyue& Chao, YuChieh& Wu, Zonggui…[et al.]. 2020. Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1157269

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Niu, Wenhao…[et al.]. Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1157269

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Niu, Wenhao& Wu, Feng& Cui, Haiming& Cao, Wenyue& Chao, YuChieh& Wu, Zonggui…[et al.]. Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1157269

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1157269