![](/images/graphics-bg.png)
A Comprehensive Network Pharmacology-Based Strategy to Investigate Multiple Mechanisms of HeChan Tablet on Lung Cancer
المؤلفون المشاركون
Wen, Junmao
Chen, Qianying
Huang, Cihui
Zhuang, Zhenjie
Huang, Haifu
Liu, Zhanhua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-30
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Background.
HeChan tablet (HCT) is a traditional Chinese medicine preparation extensively prescribed to treat lung cancer in China.
However, the pharmacological mechanisms of HCT on lung cancer remain to be elucidated.
Methods.
A comprehensive network pharmacology-based strategy was conducted to explore underlying mechanisms of HCT on lung cancer.
Putative targets and compounds of HCT were retrieved from TCMSP and BATMAN-TCM databases; related genes of lung cancer were retrieved from OMIM and DisGeNET databases; known therapeutic target genes of lung cancer were retrieved from TTD and DrugBank databases; PPI networks among target genes were constructed to filter hub genes by STRING.
Furthermore, the pathway and GO enrichment analysis of hub genes was performed by clusterProfiler, and the clinical significance of hub genes was identified by The Cancer Genome Atlas.
Result.
A total of 206 compounds and 2,433 target genes of HCT were obtained.
5,317 related genes of lung cancer and 77 known therapeutic target genes of lung cancer were identified.
507 unique target genes were identified among HCT-related genes of lung cancer and 34 unique target genes were identified among HCT-known therapeutic target genes of lung cancer.
By PPI networks, 11 target genes AKT1, TP53, MAPK8, JUN, EGFR, TNF, INS, IL-6, MYC, VEGFA, and MAPK1 were identified as major hub genes.
IL-6, JUN, EGFR, and MYC were shown to associate with the survival of lung cancer patients.
Five compounds of HCT, quercetin, luteolin, kaempferol, beta-sitosterol, and baicalein were recognized as key compounds of HCT on lung cancer.
The gene enrichment analysis implied that HCT probably benefitted patients with lung cancer by modulating the MAPK and PI3K-Akt pathways.
Conclusion.
This study predicted pharmacological and molecular mechanisms of HCT against lung cancer and could pave the way for further experimental research and clinical application of HCT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhuang, Zhenjie& Chen, Qianying& Huang, Cihui& Wen, Junmao& Huang, Haifu& Liu, Zhanhua. 2020. A Comprehensive Network Pharmacology-Based Strategy to Investigate Multiple Mechanisms of HeChan Tablet on Lung Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1157324
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhuang, Zhenjie…[et al.]. A Comprehensive Network Pharmacology-Based Strategy to Investigate Multiple Mechanisms of HeChan Tablet on Lung Cancer. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1157324
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhuang, Zhenjie& Chen, Qianying& Huang, Cihui& Wen, Junmao& Huang, Haifu& Liu, Zhanhua. A Comprehensive Network Pharmacology-Based Strategy to Investigate Multiple Mechanisms of HeChan Tablet on Lung Cancer. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1157324
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157324
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)