Phytochemical Analysis, Cytotoxic, Antioxidant, and Antibacterial Activities of Lichens
المؤلفون المشاركون
Benbacer, Laila
Bourhia, Mohammed
Laasri, Fatima Ezzahra
Aoussar, Noura
Manoljovic, Nedeljko
Mhand, Rajaa Ait
Rhallabi, Naima
Ullah, Riaz
Noman, Omar M.
Nasr, Fahd A
Almarfadi, Omer M.
El Mzibri, Mohammed
Vasiljević, Perica
Mellouki, Fouad
Shahat, Abdelaaty A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Lichens present a complex symbiotic relationship between a filamentous fungus, photoautotrophic partner (algae or cyanobacteria), and bacterial community.
The Objective of the Study.
This study aimed at investigating the chemical composition and cytotoxic, antioxidant, and antimicrobial activities of acetone extracts of Moroccan Evernia prunastri (E.
prunastri), Ramalina farinacea (R.
farinacea), and Pseudevernia furfuracea (P.
furfuracea).
Materials and Methods.
The phytochemical analysis was carried out by HPLC-UV.
The cytotoxic effect was assessed on human prostate cancer (22RV1), human colon carcinoma (HT-29), human hepatocellular carcinoma (Hep-G2), and Hamster ovarian cancer (CHO) cells lines by WST1 assay.
The antioxidant power was assessed by DPPH and FRAP assays.
The antibacterial effect was obtained using the broth microdilution method.
Results.
The findings of phytochemical analysis showed that the lichens studied possess interesting bioactive molecules such as physodalic acid, evernic acid, and usnic acid, as well as protocetraric acid.
According to the American National Cancer Institute guidelines, the WST-1 test showed that all crude extracts did not show significant cytotoxic effects against all concerous cell lines, and IC50 values ranged from 42.30 to 140.24 µg/mL.
Regarding the antioxidant activity, P.
furfuracea extract showed the highest free-radical-scavenging ability (IC50 = 498.40 µg/mL).
The most potent antibacterial extract was recorded for P.
furfuracea extract with a minimum inhibitory concentration (MIC) ranging from 0.039 to 0.31 mg/mL.
Conclusion.
In this research work, we report that the studied lichen extracts exhibit an important biological effect, supporting that lichens represent a hopeful source of original natural products for the research of new bioactive molecules having a pharmaceutical interest.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aoussar, Noura& Laasri, Fatima Ezzahra& Bourhia, Mohammed& Manoljovic, Nedeljko& Mhand, Rajaa Ait& Rhallabi, Naima…[et al.]. 2020. Phytochemical Analysis, Cytotoxic, Antioxidant, and Antibacterial Activities of Lichens. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157404
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aoussar, Noura…[et al.]. Phytochemical Analysis, Cytotoxic, Antioxidant, and Antibacterial Activities of Lichens. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1157404
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aoussar, Noura& Laasri, Fatima Ezzahra& Bourhia, Mohammed& Manoljovic, Nedeljko& Mhand, Rajaa Ait& Rhallabi, Naima…[et al.]. Phytochemical Analysis, Cytotoxic, Antioxidant, and Antibacterial Activities of Lichens. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157404
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157404
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر