Alleviating the Hydrolysis of Carbohydrates, Tangzhiqing (TZQ) Decreased the Postprandial Glycemia in Healthy Volunteers: An Eight-Period Crossover Study
المؤلفون المشاركون
Baohe, Wang
Yanfen, Li
Ziqiang, Li
Deqin, Zhang
Liu, Jia
Wang, Ruihua
Mi, Bo
Jiang, Ting
Lu, Meijuan
Xu, Qiang
Yuhong, Huang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Tangzhiqing (TZQ), a Chinese herbal medicine, has been widely used to treat diabetes mellitus in China.
TZQ works as a potential α-glucosidase inhibitor to reduce the absorption of glucose from dietary carbohydrates.
The main aim of this study was to investigate the postprandial glucose-lowering effect of TZQ on the common carbohydrates in healthy humans.
Meanwhile, the possible types of the inhibited α-glucosidase enzymes were predicted in this study.
Glucose, sucrose, maltose, maltodextrin, and starch were chosen as investigated carbohydrates.
The baseline incremental area under the curve (IAUC) and glycemic index (GI) values of the investigated carbohydrates were evaluated.
Then, thirty-six subjects were randomly assigned to three groups to assess postprandial hypoglycemic effects of 3-, 6-, and 9-tablet TZQ.
The subjects in each group were randomized to eight subgroups.
An eight-period, eight-sequence, crossover design was performed to investigate the postprandial glucose-lowering effect of TZQ after drinking each carbohydrate.
A significant decrease was observed on the postprandial glucose IAUCs (279.41 ± 111.31 vs.
203.86 ± 61.08) and GIs (124.91 ± 48.54 vs.
91.69 ± 27.47) of maltose after oral administration of 6-tablet TZQ, as well as IAUCs (145.05 ± 55.01 vs.
110.23 ± 57.03) and GIs (84.87 ± 33.40 vs.
65.50 ± 33.89) of sucrose after administration of 3-tablet TZQ.
The glucose IAUCs (109.15 ± 55.92 vs.
57.68 ± 46.09) and GIs (49.09 ± 25.15 vs.
25.94 ± 20.73) of starch statistically reduced following the administration of 6-tablet TZQ.
The lowering postprandial blood glucose effect of TZQ did not increase proportionally with increasing doses in humans.
There were no significant changes in the glucose-lowering effect of glucose and maltodextrin after the administration of 3-, 6-, or 9-tablet TZQ, respectively.
TZQ is a potential treatment for postprandial hyperglycemia, which can probably make α-glucosidases inhibit maltase, sucrase, and α-amylase in the digestive organs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yanfen, Li& Ziqiang, Li& Wang, Ruihua& Mi, Bo& Jiang, Ting& Lu, Meijuan…[et al.]. 2020. Alleviating the Hydrolysis of Carbohydrates, Tangzhiqing (TZQ) Decreased the Postprandial Glycemia in Healthy Volunteers: An Eight-Period Crossover Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yanfen, Li…[et al.]. Alleviating the Hydrolysis of Carbohydrates, Tangzhiqing (TZQ) Decreased the Postprandial Glycemia in Healthy Volunteers: An Eight-Period Crossover Study. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1157415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yanfen, Li& Ziqiang, Li& Wang, Ruihua& Mi, Bo& Jiang, Ting& Lu, Meijuan…[et al.]. Alleviating the Hydrolysis of Carbohydrates, Tangzhiqing (TZQ) Decreased the Postprandial Glycemia in Healthy Volunteers: An Eight-Period Crossover Study. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر