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A Review of Malaysian Herbal Plants and Their Active Constituents with Potential Therapeutic Applications in Sepsis
المؤلفون المشاركون
Liew, Kong Yen
Hafiz, Md Faizul
Chong, Yi Joong
Harith, Hanis Hazeera
Israf, Daud Ahmad
Tham, Chau Ling
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-28
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Sepsis refers to organ failure due to uncontrolled body immune responses towards infection.
The systemic inflammatory response triggered by pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) from Gram-negative bacteria, is accompanied by the release of various proinflammatory mediators that can lead to organ damage.
The progression to septic shock is even more life-threatening due to hypotension.
Thus, sepsis is a leading cause of death and morbidity globally.
However, current therapies are mainly symptomatic treatment and rely on the use of antibiotics.
The lack of a specific treatment demands exploration of new drugs.
Malaysian herbal plants have a long history of usage for medicinal purposes.
A total of 64 Malaysian plants commonly used in the herbal industry have been published in Malaysian Herbal Monograph 2015 and Globinmed website (http://www.globinmed.com/).
An extensive bibliographic search in databases such as PubMed, ScienceDirect, and Scopus revealed that seven of these plants have antisepsis properties, as evidenced by the therapeutic effect of their extracts or isolated compounds against sepsis-associated inflammatory responses or conditions in in vitro or/and in vivo studies.
These include Andrographis paniculata, Zingiber officinale, Curcuma longa, Piper nigrum, Syzygium aromaticum, Momordica charantia, and Centella asiatica.
Among these, Z.
officinale is the most widely studied plant and seems to have the highest potential for future therapeutic applications in sepsis.
Although both extracts as well as active constituents from these herbal plants have demonstrated potential antisepsis activity, the activity might be primarily contributed by the active constituent(s) from each of these plants, which are andrographolide (A.
paniculata), 6-gingerol and zingerone (Z.
officinale), curcumin (C.
longa), piperine and pellitorine (P.
nigrum), biflorin (S.
aromaticum), and asiaticoside, asiatic acid, and madecassoside (C.
asiatica).
These active constituents have shown great antisepsis effects, and further investigations into their clinical therapeutic potential may be worthwhile.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liew, Kong Yen& Hafiz, Md Faizul& Chong, Yi Joong& Harith, Hanis Hazeera& Israf, Daud Ahmad& Tham, Chau Ling. 2020. A Review of Malaysian Herbal Plants and Their Active Constituents with Potential Therapeutic Applications in Sepsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1157470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liew, Kong Yen…[et al.]. A Review of Malaysian Herbal Plants and Their Active Constituents with Potential Therapeutic Applications in Sepsis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1157470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liew, Kong Yen& Hafiz, Md Faizul& Chong, Yi Joong& Harith, Hanis Hazeera& Israf, Daud Ahmad& Tham, Chau Ling. A Review of Malaysian Herbal Plants and Their Active Constituents with Potential Therapeutic Applications in Sepsis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1157470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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