Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice
المؤلفون المشاركون
Xu, Wenfeng
Xu, Shuo
Zhang, Shanshan
Jin, Pengfei
Jiang, Wenqing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the influence of gut microbiota on arsenic accumulation of realgar in mice.
Methods.
Mice were treated with antibiotics to form a mouse model of gut microbial disruption.
Antibiotic-treated and normally raised mice were given 15 mg/kg, 150 mg/kg, and 750 mg/kg realgar by gavage and 0.2 mg/kg and 1 mg/kg arsenic solution by subcutaneous injection for 7 days.
The concentration of arsenic in mice whole blood was determined by inductively coupled plasma mass spectrometry (ICP-MS).
Arsenic accumulation in antibiotic-treated mice and normally raised mice was compared.
Results.
After exposure to low dose (15 mg/kg) and middle dose (150 mg/kg) of realgar, significantly, more arsenic was accumulated in the whole blood of antibiotic-treated mice compared to normally raised counterparts, which indicated that the disruption of gut microbiota could lead to higher arsenic load of realgar in mice.
The homeostasis of gut microbiota was supposed to be disrupted by high dose (750 mg/kg) of realgar because after exposure to high dose of realgar, there was no significant difference in arsenic accumulation between antibiotic-treated and normally raised mice.
Furthermore, arsenic solution was administered by subcutaneous injection to mice to investigate the influence of gut microbial differences on arsenic accumulation in addition to the absorption process, and there was no significant difference in arsenic accumulation between mice with these two different statuses of gut microbiota.
Conclusions.
Gut microbiota disruption could increase arsenic accumulation of realgar in mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Wenfeng& Zhang, Shanshan& Jiang, Wenqing& Xu, Shuo& Jin, Pengfei. 2020. Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1157545
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Wenfeng…[et al.]. Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1157545
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Wenfeng& Zhang, Shanshan& Jiang, Wenqing& Xu, Shuo& Jin, Pengfei. Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1157545
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157545
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر