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A Randomized, Triple-Blind, Placebo-Controlled, Add-On Clinical Trial to Evaluate the Efficacy of Emblica officinalis in Uncontrolled Hypertension
المؤلفون المشاركون
Ghaffari, Samad
Navabzadeh, Maryam
Ziaee, Mojtaba
Ghods, Roshanak
Hashem-Dabaghian, Fataneh
Ghobadi, Ali
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Emblica officinalis (EO) has some cardiovascular effects, and there are some animal studies that show its antihypertensive effect.
This study was conducted to determine the effect of combination of EO with standard therapy on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with uncontrolled hypertension.
Materials and Methods.
This was a randomized, triple-blind, placebo-controlled, 8-week study.
Ninety-two patients with uncontrolled hypertension despite taking hypotensive drugs were randomly assigned into two groups to take EO (500 mg/TDS after meal) or placebo in combination with standard antihypertensive drugs.
After 2, 4, 6, and 8 weeks of intervention, SBP and DBP and heart rate (HR) were measured.
Data were analyzed by SPSS software using repeated measures ANOVA.
Results.
Eighty-one patients (41 in the drug group and 40 in the placebo group) completed the study for 8 weeks and were analyzed.
The mean ± standard deviation of age was 53.64 ± 10.01 years.
SBP decreased as 15.6 ± 8.23% in the EO group and 6.3 ± 7.49% in the placebo group (P<0.001).
DBP decreased as 12.3 ± 7.87% and 3.88 ± 7.98%, respectively (P<0.001).
Time effect was not significant, but the group effect was significant (F = 13.875, P=0.001 for systolic BP and F = 18.948, P<0.001 for diastolic BP).
No side effects were reported during the study.
Conclusion.
Eight-week combination therapy of EO with standard antihypertensive drugs significantly reduced the SBP and DBP more than placebo in patients with uncontrolled hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghaffari, Samad& Navabzadeh, Maryam& Ziaee, Mojtaba& Ghobadi, Ali& Ghods, Roshanak& Hashem-Dabaghian, Fataneh. 2020. A Randomized, Triple-Blind, Placebo-Controlled, Add-On Clinical Trial to Evaluate the Efficacy of Emblica officinalis in Uncontrolled Hypertension. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1157759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghaffari, Samad…[et al.]. A Randomized, Triple-Blind, Placebo-Controlled, Add-On Clinical Trial to Evaluate the Efficacy of Emblica officinalis in Uncontrolled Hypertension. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1157759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghaffari, Samad& Navabzadeh, Maryam& Ziaee, Mojtaba& Ghobadi, Ali& Ghods, Roshanak& Hashem-Dabaghian, Fataneh. A Randomized, Triple-Blind, Placebo-Controlled, Add-On Clinical Trial to Evaluate the Efficacy of Emblica officinalis in Uncontrolled Hypertension. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1157759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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