Exploring the Antihyperglycemic Chemical Composition and Mechanisms of Tea Using Molecular Docking
المؤلفون المشاركون
Zhang, Liang
Wang, Lufei
Sun, Yue
Xiao, Hang
Shaughnessy, Lily K.
Xu, Qingliang
Shi, Xueping
Yu, Rilei
Wan, Xiaochun
Wu, Xian
Lin, Yan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Tea, a widely consumed beverage, has long been utilized for promoting human health with a close correlation to hyperglycemia.
The Tea Metabolome Database (TMDB), the most complete and comprehensive curated collection of tea compounds data containing 1271 identified small molecule compounds from the tea plant (Camellia sinensis), was established previously by our research team.
More recently, our studies have found that various tea types possess an antihyperglycemic effect in mice.
However, the bioactive ingredients from tea have potential antihyperglycemic activity and their underlying molecular mechanisms remain unclear.
In this study, we used a molecular docking approach to investigate the potential interactions between a selected 747 constituents contained in tea and 11 key protein targets of clinical antihyperglycemic drugs.
According to our results, the main antihyperglycemic targets of tea composition were consistent with those of the drug rosiglitazone.
The screening results showed that GCG, ECG3’Me, TMDB-01443, and CG had great target binding capacity.
The results indicated that these chemicals of tea might affect hyperglycemia by acting on protein targets of rosiglitazone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Yue& Wang, Lufei& Shaughnessy, Lily K.& Lin, Yan& Xu, Qingliang& Shi, Xueping…[et al.]. 2020. Exploring the Antihyperglycemic Chemical Composition and Mechanisms of Tea Using Molecular Docking. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158142
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Yue…[et al.]. Exploring the Antihyperglycemic Chemical Composition and Mechanisms of Tea Using Molecular Docking. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1158142
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Yue& Wang, Lufei& Shaughnessy, Lily K.& Lin, Yan& Xu, Qingliang& Shi, Xueping…[et al.]. Exploring the Antihyperglycemic Chemical Composition and Mechanisms of Tea Using Molecular Docking. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158142
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158142
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر