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Deciphering the Key Pharmacological Pathways and Targets of Yisui Qinghuang Powder That Acts on Myelodysplastic Syndromes Using a Network Pharmacology-Based Strategy
المؤلفون المشاركون
Ding, Yang
Han, Zijian
Song, Luping
Qi, Kele
Wei, Mingjun
Jia, Yongcun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-08
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Yisui Qinghuang powder (YSQHP) is an effective traditional Chinese medicinal formulation used for the treatment of myelodysplastic syndromes (MDS).
However, its pharmacological mechanism of action is unclear.
Materials and Methods.
In this study, the active compounds of YSQHP were screened using the traditional Chinese medicine systems pharmacology (TCMSP) and HerDing databases, and the putative target genes of YSQHP were predicted using the STITCH and DrugBank databases.
Then, we further screened the correlative biotargets of YSQHP and MDS.
Finally, the compound-target-disease (C-T-D) network was conducted using Cytoscape, while GO and KEGG analyses were conducted using R software.
Furthermore, DDI-CPI, a web molecular docking analysis tool, was used to verify potential targets and pathways.
Finally, binding site analysis was performed to identify core targets using MOE software.
Results.
Our results identified 19 active compounds and 273 putative target genes of YSQHP.
The findings of the C-T-D network revealed that Rb1, CASP3, BCL2, and MAPK3 showed the most number of interactions, whereas indirubin, tryptanthrin, G-Rg1, G-Rb1, and G-Rh2 showed the most number of potential targets.
The GO analysis showed that 17 proteins were related with STPK activity, PUP ligase binding, and kinase regulator activity.
The KEGG analysis showed that PI3K/AKT, apoptosis, and the p53 pathways were the main pathways involved.
DDI-CPI identified the top 25 proteins related with PI3K/AKT, apoptosis, and the p53 pathways.
CASP8, GSK3B, PRKCA, and VEGFR2 were identified as the correlative biotargets of DDI-CPI and PPI, and their binding sites were found to be indirubin, G-Rh2, and G-Rf.
Conclusion.
Taken together, our results revealed that YSQHP likely exerts its antitumor effects by binding to CASP8, GSK3B, PRKCA, and VEGFR2 and by regulating the apoptosis, p53, and PI3K/AKT pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Zijian& Song, Luping& Qi, Kele& Ding, Yang& Wei, Mingjun& Jia, Yongcun. 2020. Deciphering the Key Pharmacological Pathways and Targets of Yisui Qinghuang Powder That Acts on Myelodysplastic Syndromes Using a Network Pharmacology-Based Strategy. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158166
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Zijian…[et al.]. Deciphering the Key Pharmacological Pathways and Targets of Yisui Qinghuang Powder That Acts on Myelodysplastic Syndromes Using a Network Pharmacology-Based Strategy. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1158166
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Zijian& Song, Luping& Qi, Kele& Ding, Yang& Wei, Mingjun& Jia, Yongcun. Deciphering the Key Pharmacological Pathways and Targets of Yisui Qinghuang Powder That Acts on Myelodysplastic Syndromes Using a Network Pharmacology-Based Strategy. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158166
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158166
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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