Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential
المؤلفون المشاركون
Kuete, Victor
Ntyam Mendo, Samuel A.
Nguenang, Gaëlle S.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Lycopersicon esculentum (tomato) is a plant widely used in Africa like food and to solve many health problems.
The methanol crude extract of tomato recently demonstrated a good antiproliferative effect on many human cancer cell lines.
The aim of this research was to evaluate the acute toxicity and subacute oral toxicity of methanolic extract from leaves of this plant.
These toxicities were evaluated based on the OECD (Organization for Economic Cooperation and Development) guidelines.
The assay of acute toxicity was performed using a total of 3 female rats, which received a single dose of 5000 mg/kg of methanolic extract via oral gavage.
For the subacute toxicity study, 32 Wistar rats (males and females) were used.
The groups were treated with three different doses of Lycopersicon esculentum methanolic extract (250, 500, and 1000 mg/kg b.w.) for 28 days and the control group received distilled water.
The hematological, biochemical, and histopathological studies were performed after the sacrifice.
Single dose of tomato extract caused no toxicity up to a dose of 5000 mg/kg body weight; hence, the median lethal dose (DL50) of leaves of this plant was greater than this value.
However, lower toxic effects could be manifested in the long-term treatment at the highest dose (1000 mg/kg) because urea level and total serum proteins significantly increased at a dose of 1000 mg/kg with respect to control.
The microscopic observation showed no remarkable pathological changes on all organs in the treated groups compared with the control groups of female and male rats.
These results demonstrate that single dose of tomato extract leaves is relatively nontoxic at a dose of 5000 mg/kg b.w.
and prolonged use of lower doses (250 and 500 mg/kg) of L.
esculentum orally should be encouraged, whereas highest dose (1000 mg/kg) should be avoided.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nguenang, Gaëlle S.& Ntyam Mendo, Samuel A.& Kuete, Victor. 2020. Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1158267
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nguenang, Gaëlle S.…[et al.]. Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1158267
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nguenang, Gaëlle S.& Ntyam Mendo, Samuel A.& Kuete, Victor. Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1158267
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158267
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر