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Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK12 Pathway and SIRT1 Modulation
المؤلفون المشاركون
Udomruk, Sasimol
Kaewmool, Chayanut
Phitak, Thanyaluck
Pothacharoen, Peraphan
Kongtawelert, Prachya
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The promotion of neurogenesis can be a promising strategy to improve and restore neuronal function in neurodegenerative diseases.
Nerve growth factor (NGF) plays a key role in neurite outgrowth and synaptic formation during brain repair stage.
Nowadays, there are several studies on the developing methods to enhance the endogenous NGF activity for treatment and restore the neuronal function.
In this study, the potentiating effect of sesamin, a major lignan in sesame seeds (Sesamum indicum) and oil, on NGF-induced neurogenesis and its involved mechanisms were firstly reported.
Sesamin effectively enhanced the PC12 neuron-like cell differentiation and neurite length under insufficient conditions of NGF.
The neuronal markers including synaptophysin and growth-associated protein-43 along with the synaptic connections were significantly increased in combination treatment between sesamin and NGF.
Moreover, sesamin also increased the level of phospho-ERK1/2 and SIRT1 protein, an important regulatory protein of the neurogenesis process.
The neurogenesis was blocked by the specific SIRT1 inhibitor, JGB1741, suggesting that the neuritogenic effect of sesamin was associated with SIRT1 protein modulation.
Taken together, the potentiating effect of sesamin on NGF-induced neurogenesis in this finding could be used for alternative treatment in neurodegenerative diseases, including Alzheimer’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Udomruk, Sasimol& Kaewmool, Chayanut& Phitak, Thanyaluck& Pothacharoen, Peraphan& Kongtawelert, Prachya. 2020. Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK12 Pathway and SIRT1 Modulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158381
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Udomruk, Sasimol…[et al.]. Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK12 Pathway and SIRT1 Modulation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1158381
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Udomruk, Sasimol& Kaewmool, Chayanut& Phitak, Thanyaluck& Pothacharoen, Peraphan& Kongtawelert, Prachya. Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK12 Pathway and SIRT1 Modulation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158381
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158381
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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